An Acute Negative Bystander Effect of γ-Irradiated Recipients on Transplanted Hematopoietic Stem Cells in Mice In this study, researchers found that irradiated mouse recipients significantly impaired the long-term repopulating ability of transplanted mouse hematopoietic stem cells shortly (~17 hours) after exposure to irradiated hosts and before the cells began to divide. [Blood] Abstract Umbilical Cord Stem Cells Released from Alginate-Fibrin Microbeads Inside Macroporous and Biofunctionalized Calcium Phosphate Cement for Bone Regeneration The objectives of this study were to develop a novel biofunctionalized and macroporous calcium phosphate cement (CPC) containing alginate-fibrin microbeads encapsulating human umbilical cord mesenchymal stem cells (hUCMSCs) and investigate hUCMSC proliferation and osteogenic differentiation inside CPC for the first time. [Acta Biomater] Abstract Reconstruction of Hematopoietic Inductive Microenvironment after Transplantation of Vascular Cell Adhesion Molecule-1-Modified Human Umbilical Cord Blood Stromal Cells In this study, researchers first established a co-culture system of human cord blood-derived stromal cells (HUCBSCs) and cord blood CD34+ cells and then determined that using HUCBSCs as the adherent layer had significantly more newly formed colonies of each hematopoietic lineage than the control group, indicating that HUCBSCs had the ability to promote the proliferation of hematopoietic stem cells/progenitor cells. [PLoS One] Abstract Cooperation of Epac1/Ras-Related Protein 1/Akt and PKA in Prostaglandin E2-Induced Proliferation of Human Umbilical Cord Blood Derived Mesenchymal Stem Cells: Involvement of c-Myc and Vascular Endothelial Growth Factor Expression Researchers investigated the relationship between the exchange protein directly activated by cAMP (Epac1) and protein kinase A (PKA) during prostaglandin E2-induced human umbilical cord blood-derived mesenchymal stem cells proliferation and its related signaling pathways. [J Cell Physiol] Abstract Enhanced Humoral and HLA-A2-Restricted Dengue Virus-Specific T Cell Responses in Humanized BLT NSG Mice Researchers recently described an animal model for dengue virus (DENV) infection using humanized NOD-scid IL2rγnull mice (NSG) engrafted with cord blood hematopoietic stem cells. The researchers sought to further improve this model by co-transplantation of human fetal thymus and liver tissues into NSG (BLT-NSG) mice. [Immunology] Abstract Clostridium difficile Infection after Allogeneic Hematopoietic Stem Cell Transplantation: Incidence, Risk Factors and Outcome The purpose of this study was to evaluate the incidence, risk factors and outcome of C. difficile infection after hematopoietic stem cell transplantation. [Biol Blood Marrow Transplant] Abstract Single-Cell Level Analysis of Megakaryocyte Growth and Development Herein, long-term and large-field live cell imaging was used to study the process of megakaryopoiesis at the single cell level from human CD34+ cord blood in the presence of thrombopoietin or the cytokine cocktail BS1 with or without nicotinamide. [Differentiation] Abstract The Impact of Hyaluronan on Monocyte Toll-Like Receptor Expression in Term Infant Cord Blood The aim of this study was explore the possible effects of hyaluronan on monocyte surface expression of Toll-like receptor 2 and -4 in human umbilical cord blood ex vivo, and in a model mimicking Gram-negative neonatal sepsis. [Acta Paediatr] Abstract |