Proteomic Validation of Multifunctional Molecules in Mesenchymal Stem Cells Derived from Human Bone Marrow, Umbilical Cord Blood and Peripheral Blood To understand the different molecular conditions that govern the different application or differentiation potential of each mesenchymal stem cell (MSC) according to cellular source, scientists generated a proteome reference map of MSCs obtained from bone marrow, umbilical cord blood and peripheral blood. [PLoS One] Full Article Bmi1 Confers Resistance to Oxidative Stress on Hematopoietic Stem Cells Researchers demonstrated that overexpression of Bmi1 confers resistance to stresses, particularly oxidative stress, onto hematopoietic stem cells. [PLoS One] Full Article Irradiated Allogeneic Cells Enhance Umbilical Cord Blood Stem Cell Engraftment in Immunodeficient Mice Researchers performed experiments to determine if adjunctive therapy with third-party human allogeneic cells enhances the engraftment of human umbilical cord blood in immunodeficient mice. [Bone Marrow Transplant] Abstract Beneficial Effects of Non-Matched Allogeneic Cord Blood Mononuclear Cells upon Patients with Idiopathic Osteoporosis To study the benefit of blood mononuclear cell therapy, eight patients with idiopathic osteoporosis were given intermittent treatments with non-matched allogeneic cord blood mononuclear cells for three months. [J Transl Med] Full Article Cryopreservation of Human Vascular Umbilical Cord Cells Under Good Manufacturing Practice Conditions for Future Cell Banks Human umbilical cord artery derived cells and human umbilical vein endothelial cells were isolated, cultivated, cryopreserved directly after primary culture and recultivated subsequently. Cell viability, expression of cellular markers and proliferation potential of fresh and cryopreserved cells were studied using trypan blue staining, flow cytometry analysis, immunofluorescence staining and proliferation assays. [J Transl Med] Full Article Optimizing Megakaryocyte Polyploidization by Targeting Multiple Pathways of Cytokinesis Megakaryocytes were derived from umbilical cord blood and cultured with reagents that inhibit distinct mechanisms of cytokinesis. Combinations of reagents were used to determine their interactions and to maximize megakaryocyte ploidy. [Transfusion] Abstract The Prevalence of Intracellular Galectin-1-Expressing Lymphocytes in Umbilical Cord Blood in Comparison with Adult Peripheral Blood Investigators aimed to determine the properties of intracellular galectin-1-producing cells within CD3, CD4, CD8, regulatory T and NK cells in umbilical cord blood compared to adult peripheral blood. [Biol Blood Marrow Transplant] Abstract Candidate Biomarkers for Acute Rejection of Pregnancy after In Utero Cell-Based Therapy in Pre-Immune Embryos via Ultrasound-Guided Celocentesis The maternal serum concentrations of nine candidate biomarkers for acute rejection of pregnancy were determined before and after the injection of different cocktails of human umbilical cord blood stem cells into the gestational sac. [Am J Reprod Immunol] Abstract |