The Novel Tribody [(CD20)2 × CD16] Efficiently Triggers Effector Cell-Mediated Lysis of Malignant B Cells In mice with a reconstituted humanized hematopoietic system established by transplantation of human CD34-positive cord blood cells the novel tribody [(CD20)2 × CD16] significantly depleted autologous human B cells. [Leukemia] Abstract Amniotic Fluid Stem Cells Restore the Muscle Cell Niche in a HSA–Cre, SmnF7/F7 Mouse Model Mice carrying a homozygous deletion of the survival of motor neuron gene (Smn) exon 7 directed to skeletal muscle (HSA–Cre, SmnF7/F7 mice) present clinical features of human muscular dystrophies for which new therapeutic approaches are highly warranted. In this study, researchers demonstrated that tail vein transplantation of mouse amniotic fluid stem cells enhances the muscle strength and improves the survival rate of the affected animals. [Stem Cells] Abstract | Press Release Cobalt Chloride Enhances Angiogenic Potential of CD133+ Cells Investigators determined whether CD133+ cells enhance angiogenic potential through hypoxia or hypoxia mimetic agent (CoCl2) in vitro. [Front Biosci] Abstract Toxicity of Clopidogrel and Ticlopidine on Human Myeloid Progenitor Cells: Importance of Metabolites Aims of this study were to find out whether non-metabolized drug and/or metabolites are responsible for myelotoxicity and whether the inactive clopidogrel metabolite clopidogrel carboxylate contributes to myelotoxicity. Researchers used myeloid progenitor cells isolated from human umbilical cord blood in a colony-forming unit assay to assess cytotoxicity. [Toxicology] Abstract Ex Vivo Expansion of Cord Blood-CD34+ Cells Using IGFBP2 and Angptl-5 Impairs Short-Term Lymphoid Repopulation In Vivo The yield of cord blood (CB)-derived hematopoietic stem cells per graft is limited and often insufficient, particularly for the treatment of adult patients. Here researchers compared the capacity of three cytokine cocktails to expand CB-CD34+ cells. [J Tissue Eng Regen Med] Abstract Combination of Temperature Sensitive Stem Cell and Mild Hypothermia: A New Potential Therapy for Severe Traumatic Brain Injury The authors observed that combinational therapy of hypothermia and temperature sensitive mesenchymal stem cells from umbilical cord exerted the most protective effect on recovery of neurological function among all treatments with highest survival rate, proliferation and lowest apoptosis, which may provide a new therapeutic strategy for severe traumatic brain injury. [J Neurotrauma] Abstract Human Umbilical Cord Blood-Derived Mesenchymal Stem Cell Transplantation Attenuates Severe Brain Injury by Permanent Middle Cerebral Artery Occlusion in Newborn Rats Researchers hypothesized that human umbilical cord blood-derived mesenchymal stem cells can attenuate severe brain injury induced by permanent middle cerebral artery occlusion in rat pups. [Pediatr Res] Abstract Systemic Delivery of Human Mesenchymal Stromal Cells Combined with IGF-1 Enhances Muscle Functional Recovery in LAMA2dy/2j Dystrophic Mice Scientists demonstrated that IGF-1 considerably enhances the myogenesis of human umbilical cord mesenchymal stromal cells (MSCs) in vitro and that IGF-1 enhances interaction and restoration of dystrophin expression in co-cultures of MSCs and muscle cells from Duchenne patients. [Stem Cell Rev] Abstract |