| PUBLICATIONS (Ranked by impact factor of the journal) | Analysis of Incidence, Risk Factors and Clinical Outcome of Thromboembolic and Bleeding Events in 431 Allogeneic Hematopoietic Stem Cell Transplantation Recipients Investigators retrospectively analyzed data from 431 allogeneic transplantation recipients to identify the incidence, risk factors and mortality due to thrombosis and bleeding. [Haematologica] Abstract | Full Article Human Amniotic Fluid Stem Cell Injection Therapy for Urethral Sphincter Regeneration in an Animal Model Researchers investigated whether periurethral injection of human amniotic fluid stem cells can restore urethral sphincter competency in a mouse model. [BMC Med] Abstract | Full Article | Press Release Human Umbilical Cord Stem Cell Encapsulation in Novel Macroporous and Injectable Fibrin for Muscle Tissue Engineering Researchers aimed to seed human umbilical cord mesenchymal stem cells in a fibrin hydrogel containing fast-degradable microbeads to create macropores to enhance cell viability and to investigate the encapsulated cell proliferation and myogenic differentiation for muscle tissue engineering. [Acta Biomater] Abstract Pkb/Akt1 Mediates Wnt/GSK3β/β-Catenin Signaling-Induced Apoptosis in Human Cord Blood Stem Cells Exposed to Organophosphate Pesticide Monocrotophos Inhibition mechanisms of protein kinase B (Pkb)/Akt and its consequences on related cell signaling were investigated in human umbilical cord blood stem cells exposed to monocrotophos. [Stem Cells Dev] Abstract Growth Factor-Activated Stem Cell Circuits and Stromal Signals Cooperatively Accelerate Non-Integrated iPSC Reprogramming of Human Myeloid Progenitors Investigators report highly optimized four-factor reprogramming of lineage-committed cord blood myeloid progenitors with bulk efficiencies of ~50% in purified episome-expressing cells. The efficient conversion of mature myeloid populations into NANOG+TRA-1-81+ human induced pluripotent stem cells (iPSCs) was mediated by synergies between hematopoietic growth factor, stromal activation signals, and episomal Yamanaka factor expression. [PLoS One] Full Article | Press Release Mesenchymal Stromal Cells of Human Umbilical Cord Wharton's Jelly Accelerate Wound Healing by Paracrine Mechanisms Human umbilical cord perivascular cells (HUCPVC) were isolated, and their proliferation rate, marker expression and multilineage differentiation potential determined. HUCPVC or their conditioned medium were injected into the excisional wound of a mouse splinted-wound model. The effects of the treatment on wound closure were examined by morphohistochemical and gene expression analyses. [Cytotherapy] Abstract Insulin-Like Growth Factor-I Regulates the Neonatal Immune Response in Infection and Maturation by Suppression of IFN-γ Immunosuppression by insulin-like growth factor-I (IGF-I) might be a key regulator of neonatal immune responses in infection and maturation. However, information on IGF-I serum levels, IGF-I-receptor and effects on functional properties of neonatal immune cells is scarce. Neonatal cord blood samples were stimulated with anti-CD3/anti-CD28, PMA/ionomycin or LPS in a whole-blood assay, while IGF-I serum levels and IGF-I receptor expression were assessed. [Cytokine] Abstract Stemness of Human Wharton's Jelly Mesenchymal Cells Is Maintained by Floating Cultivation Researchers characterized and maintained the stemness characteristics of mesenchymal stem cells for Wharton's jelly. Wharton's jelly cells were isolated, adhered to culture plates, and characterized for stem cell and surface markers expression. [Cell Reprogram] Abstract |
| NEW! REVIEWS Based on your feedback, we've added a Reviews section to Cord Blood News | Enhancing Engraftment of Cord Blood Cells via Insight into the Biology of Stem/Progenitor Cell Function This review provides information about the general field of cord blood (CB) transplantation and about studies that focus on regulation of hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs) by CD26/DPPIV, SDF-1/CXCL12, the Rheb2-mTOR pathway, SIRT1, DEK, cyclin-dependent kinase inhibitors, and cytokines/growth factors. Cryopreservation of CB HSCs and HPCs is also briefly discussed. [Ann N Y Acad Sci] Abstract |
|
|
|