New Autoimmune Diseases after Cord Blood Transplantation: A Retrospective Study of EUROCORD and the Autoimmune Disease Working Party of EBMT To describe incidence, risk factors and treatment of autoimmune diseases (AD) occurring after cord blood transplantation (CBT), researchers analyzed CBT recipients reported to EUROCORD having developed at least one new AD and those having not. [Blood] Abstract Prospective Multicenter Study of Single-Unit Cord Blood Transplantation with Myeloablative Conditioning for Adult Patients with High-Risk Hematological Malignancies Researchers assessed the safety and efficacy of cord blood transplantation performed precisely according to the transplant procedures of the Institute of Medical Science, University of Tokyo. [Biol Blood Marrow Transplant] Abstract Transplant-Related Mortality, Graft Failure and Survival following Reduced Toxicity Conditioning and Allogeneic Hematopoietic Stem Cell Transplantation in 100 Consecutive Pediatric Recipients Myeloablative conditioning and AlloHSCT is associated with a 10-40% risk of day +100 transplant-related mortality. The authors evaluated the feasibility and safety of reduced toxicity conditioning and AlloHSCT in 100 consecutive children and adolescent recipients. [Biol Blood Marrow Transplant] Abstract Double Umbilical Cord Blood Transplantation in Patients with Hematologic Malignancies Using a Reduced-Intensity Preparative Regimen without Antithymocyte Globulin Researchers report the results of a non-antithymocyte globulin-containing reduced-intensity conditioning regimen, where patients received 2 Gy TBI unless they were considered to be at higher risk of graft failure, in which case they received 3 Gy of TBI. Thirty patients underwent cord blood transplants using this protocol for high-risk hematological malignancies. [Bone Marrow Transplant] Abstract Mesenchymal Stem Cells Support Proliferation and Terminal Differentiation of B Cells The effect of human umbilical cord mesenchymal stem cells (MSC) on proliferation and differentiation of B-cells were characterized in vitro, and researchers also tested the immunoregulatory properties of mouse bone marrow MSC on T cell dependent and independent antibody production in vivo in mice. [Cell Physiol Biochem] Abstract | Full Article Effects of Telomerase Activity and Apoptosis on Ex Vivo Expansion of Cord Blood CD34+ Cells Change in telomerase activity and level of apoptosis in cord blood CD34+ cells were evaluated together with specific cell population growth rate during ex vivo culture. [Cell Prolif] Abstract The Allogeneic Umbilical Cord Mesenchymal Stem Cells Regulate the Function of T Helper 17 Cells from Patients with Rheumatoid Arthritis in an In Vitro Co-Culture System To investigate the immunoregulatory effect of stem cell transplantation, human umbilical cord mesenchymal stem cells were co-cultured with peripheral blood mononuclear cells from patients with rheumatoid arthritis. [BMC Musculoskelet Disord] Abstract | Full Article A Novel Filtration Method for Cord Blood Processing Using a Polyester Fabric Filter Investigators developed a novel filtration system using a nonchemical-coated and nonwoven polyester fabric filter, which traps cells through affinity and does not require centrifugation or potentially toxic chemicals. Cell processing with the device resulted in minimum cell loss of total cells and CD34+ cells, without impairing the ability of CD34+ cells to engraft and differentiate both in vivo and in vitro. [Int J Lab Hematol] Abstract |