Cord Blood News Volume 5.25 | Jun 27 2013

IFN-Gamma Stimulated Human Umbilical-Tissue Derived Cells Potently Suppress NK Activation and Resist NK Mediated Cytotoxicity In Vitro
Scientists evaluated in vitro Natural Killer (NK) cell interactions with human umbilical tissue-derived cells (hUTC) and compared it to human mesenchymal stem cells. Their investigations showed that hUTC suppress NK activation, through prostaglandin-E2 secretion in a contact independent manner. [Stem Cells Dev] Abstract

Inhibitory Effect of Glyceollins on Vasculogenesis through Suppression of Endothelial Progenitor Cell Function
Investigators aimed to determine the effect of glyceollin treatment on endothelial progenitor cells (EPCs) during early tumor vasculogenesis. They found that glyceollin treatment significantly decreased the number of EPC colony-forming units in human cord blood-derived AC133⁺ cells and mouse bone-marrow-derived c-Kit⁺/Sca-1⁺/Lin^– cells. [Mol Nutr Food Res] Abstract

Maturation of CD4⁺ Regulatory T Lymphocytes and of Cytokine Secretions in Infants Born Prematurely
The proportions of CD4⁺ regulatory T lymphocyte cells, their phenotypic characteristics, and the mitogen-induced cytokine productions by peripheral blood mononuclear cells were analyz ed in 26 very-preterm infants from 2 to 16 months of age, and compared to results obtained for 17 cord blood mononuclear cells from very-preterm infants, 12 from term infants and to blood samples from 40 adults. [J Clin Immunol] Abstract

Unrelated Cord Blood Transplantation for Central Nervous System Relapse in High-Risk Childhood Acute Lymphoblastic Leukemia
Scientists aimed to identify the potential benefits of unrelated cord blood transplantation in high-risk childhood acute lymphoblastic leukemia with central nervous system (CNS) relapse who has been treated on CNS-directed treatment strategies. [Ann Hematol] Abstract

Human Umbilical-Cord-Blood Mononucleated Cells Enhance the Survival of Lethally Irradiated Mice: Dosage and the Window of Time
Researchers evaluated the window of time and dose of human umbilical-cord-blood mononucleated cells necessary for successful treatment of radiation injury in mice. [J Radiat Res] Full Article

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SCRM Building Wins New Laboratory Building of the Year Award
The Scottish Centre for Regenerative Medicine (SCRM) building has been named as best new laboratory building in the S-Lab Awards, which recognize laboratories for sustainability, safety and success. [MRC Centre for Regenerative Medicine] Press Release

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Postdoctoral Positions – Stem Cell Biology and Epigenetics (University of Wisconsin-Madison)

Director of Cell Processing Facility (S L Collins Associates, Inc.)

Postdoctoral Researcher – Basic and Translational Hemato-Oncology (Josep Carreras Leukaemia Research Institute)

Laboratory Manager – Basic and Translational Hemato-Oncology (Josep Carreras Leukaemia Research Institute)

PhD Student Position – Hematopoietic Stem Cells (Katholieke Universiteit Leuven)

Postdoctoral Researcher – Hematopoietic Stem Cells (Albert Einstein College of Medicine)

Assistant Professor – Stem Cell Transplantation (Boston Children’s Hospital/Harvard Medical School)

Postdoctoral Fellow – Stem Cell and Cancer Biology (Johns Hopkins University School of Medicine)

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