Long-Term Self-Renewal of Human Pluripotent Stem Cells on Peptide-Decorated poly(OEGMA-co-HEMA) Brushes under Fully Defined Conditions Human induced pluripotent stem cells generated from umbilical cord mesenchymal cells were successfully cultured for ten passages on the peptide-tethered poly(OEGMA-co-HEMA) brushes for the first time. [Acta Biomater] Abstract Induction of Dopaminergic Neurons from Human Wharton’s Jelly Mesenchymal Stem Cell by Forskolin Researchers investigated the Wharton’s jelly mesenchymal stem cells (hWJMSC) differentiation ability toward neuronal fate. The trans-differentiation of hWJMSC into neural lineage was investigated in presence of forskolin, an agent known to increase the intracellular levels of cAMP. Abstract A Simple Model System Enabling Human CD34+ Cells to Undertake Differentiation Towards T Cells Researchers provided direct evidence for the capacity of human cord blood CD34+ cells to differentiate along the T lineage in a simple human model system. Productive commitment of the CD34+ cells to generate T cells was found to be dependent on a three-dimensional matrix which induced the up-regulation of the Notch delta-like ligand 4 by epithelial cells. [PLoS One] Full Article Fucosyltransferase VII Improves the Function of Selectin Ligands on Cord Blood Hematopoietic Stem Cells Scientists determined whether surface fucosylation with α1,3 fucosyltransferase VII, which is primarily expressed by hematopoietic cells, improves the function of selectin ligands on cord blood-hematopoietic stem/progenitor cells in comparison with α1,3 fucosyltransferase VI. [Glycobiology] Abstract The Stimulation of Osteogenic Differentiation of Mesenchymal Stem Cells and VEGF Secretion of Endothelial Cells by β-CaSiO3/β-Ca3(PO4)2 Scaffolds Investigators recreated an extracellular environment using extracts of β-CaSiO3/β-Ca3(PO4)2 composites developed in their previous in vivo study, and investigated the effects of the extracts on osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells and its related mechanisms. The angiogenic potential of the extracts was also evaluated using human umbilical vein endothelial cells. [J Biomed Mater Res A] Abstract In Vitro Fabrication of Autologous Living Tissue-Engineered Vascular Grafts Based on Prenatally Harvested Ovine Amniotic Fluid-Derived Stem Cells Researchers investigated the isolation and use of autologous ovine amniotic fluid cells as cell source for cardiovascular tissue engineering applications. [J Biomed Mater Res A] Abstract Placenta Mesenchymal Stem Cell Accelerates Wound Healing by Enhancing Angiogenesis in Diabetic Goto-Kakizaki(GK) Rats Investigators examined the potential biological function of human placenta-derived mesenchymal stem cells in wound healing in diabetic Goto-Kakizaki rats. [Biochem Biophys Res Commun] Abstract Characteristics of Mesenchymal Stem Cells Derived from Wharton’s Jelly of Human Umbilical Cord and for Fabrication of Non-Scaffold Tissue-Engineered Cartilage The authors isolated mesenchymal stem cells from Wharton’s jelly of human umbilical cord, which expressed CD44, CD105 and CD271 but not CD34 and CD45 with flow cytometry analysis. RT-PCR showed not only positive expression of CD90, c-kit, Sca1, SH2 and SH3 but also positive expression of the chondrocyte markers Sox-9 and Col-2A1. [J Biosci Bioeng] Abstract |