Tumor Necrosis Factor-α-Activated Mesenchymal Stem Cells Promote Endothelial Progenitor Cell Homing and Angiogenesis Immunodepletion of IL-6 and IL-8 resulted in attenuated tumor necrosis factor-α-treated conditioned medium (TNF-α CM)-stimulated tissue repair, blood perfusion, and angiogenesis. In addition, TNF-α CM induced migration of human cord blood-derived endothelial progenitor cells through IL-6- and IL-8-dependent mechanisms in vitro. [Biochim Biophys Acta] Abstract Phosphatidylethanolamine Binding Protein 1 in Vascular Endothelial Cell Autophagy and Atherosclerosis To investigate the mechanism of phosphatidylcholine-specific phospholipase C (PC-PLC) action, the authors initially identified phosphatidylethanolamine binding protein 1 (PEBP1) as a binding partner of PC-PLC by using mass spectrometry. They found that PEBP1 positively regulated PC-PLC activity in human umbilical vein endothelial cells, and inhibition of PC-PLC by its inhibitor D609 suppressed PEBP1 expression dramatically. [J Physiol] Abstract Human Umbilical Cord Mesenchymal Stem Cell Therapy for Patients with Active Rheumatoid Arthritis: Safety and Efficacy Scientists assessed the safety and efficacy of human umbilical cord mesenchymal stem cells (UC-MSCs) in the treatment of rheumatoid arthritis (RA). In this ongoing cohort, 172 patients with active RA who had inadequate responses to traditional medication were enrolled. Patients were divided into two groups for different treatment: Disease modifying anti-rheumatic drugs (DMARDs) plus medium without UC-MSCs, or DMARDs plus UC-MSCs group via intravenous injection. [Stem Cells Dev] Abstract Impact of HLA Mismatch Direction on Outcomes after Umbilical Cord Blood Transplantation for Hematological Malignant Disorders: A Retrospective Eurocord-EBMT Analysis Scientists focused on confirming, using an independent population, whether transplantation outcomes would be different when HLA mismatch direction was considered. They analyzed 1565 patients who received a single-unit umbilical cord blood transplantation for malignant disease. [Bone Marrow Transplant] Abstract Hydrostatic Pressure and Shear Stress Affect Endothelin-1 and Nitric Oxide Release by Endothelial Cells in Bioreactors Using the bioreactor systems, endothelin-1 and nitric oxide release from human umbilical vein endothelial cells were measured in varying conditions of shear stress and pressure. [Biotechnol J] Abstract Hyperbaric Oxygen Improves Engraftment of Ex-Vivo Expanded and Gene Transduced Human CD34+ Cells in a Murine Model of Umbilical Cord Blood Transplantation Researchers evaluated the use of hyperbaric oxygen therapy as an intervention to improve human umbilical cord blood (UCB) stem/progenitor cell engraftment in an immune deficient mouse model. Six- to eight-week old NSG mice were sublethally irradiated 24 hours prior to CD34+ UCB cell transplant. [Blood Cells Mol Dis] Abstract B-Cell Function after Unrelated Umbilical Cord Blood Transplantation Using a Minimal-Intensity Conditioning Regimen in Patients with X-SCID Scientists performed reduced-intensity conditioning, consisting of fludarabine 125 mg/m2 and melphalan 80 mg/m2, prior to unrelated umbilical cord blood transplantation for five patients with X-linked severe combined immunodeficiency (X-SCID), none of them had an HLA-identical donor. [Int J Hematol] Abstract Reduced-Intensity Conditioning Followed by Cord Blood Transplantation in a Patient with Refractory Folliculotropic Mycosis Fungoides Cord blood has been used as an alternative stem cell source; however, there are few reports of mycosis fungoides (MF) patients treated using cord blood transplantation. Researchers report a rare case of refractory folliculotropic MF, which was treated with reduced-intensity conditioning followed by cord blood transplantation. [Int J Hematol] Abstract |