Significance of Soluble Growth Factors in the Chondrogenic Response of Human Umbilical Cord Matrix Stem Cells in a Porous Three Dimensional Scaffold Scientists demonstrated the in vitro chondrogenesis of human umbilical cord matrix mesenchymal stem cells in three dimensional PVA-PCL (polyvinyl alcohol-polycaprolactone) scaffolds in the presence of the individual growth factors TGFβ1, TGFβ3, IGF, BMP2 and their combination with BMP2. [Eur Cell Mater] Abstract | Full Article MSCs vs. MSCs Combined with CB for Engraftment Failure Following Autologous Hematopoietic Stem Cell Transplantation: A Pilot Prospective, Open-Labeled, Randomized Trial Researchers prospectively evaluated the effects and safeties of mesenchymal stem cells (MSCs) alone and combined with cord blood (CB) for engraftment failure. Twenty two patients were randomized to receive MSCs or MSCs plus CB. [Biol Blood Marrow Transplant] Abstract Treatment with Placenta-Derived Mesenchymal Stem Cells Mitigates Development of Bronchiolitis Obliterans in a Murine Model Researchers investigated the hypothesis that treatment with placenta-derived human mesenchymal stem cells reduces the development of bronchiolitis obliterans in a murine heterotopic tracheal transplant model. [J Thorac Cardiovasc Surg] Abstract Inhibition of Non-Muscle Myosin II Leads to G0/G1 Arrest of Wharton’s Jelly-Derived Mesenchymal Stromal Cells When cultured in the presence of blebbistatin, an inhibitor of non-muscle myosin II adenosine triphosphatase activity, Wharton’s jelly-derived mesenchymal stromal cells exhibited dose-dependent reduction in proliferative potential along with increase in cell size and induction of early senescence. [Cytotherapy] Abstract Amniotic Fluid Stem Cells Prevent β-Cell Injury Investigators used a chemically induced mouse model of type 1 diabetes to determine whether amniotic fluid stem cells could play a role in modulating β-cell injury and restoring β-cell function. [Cytotherapy] Abstract Sunitinib Effects on the Radiation Response of Endothelial and Breast Tumor Cells Investigators conducted experiments in vitro to discern the effects of radiation combined with the anti-angiogenic Sunitinib on endothelial (HUVEC) and tumor (MDA-MB-231) cells, and further compared findings to results obtained in vivo. [Microvasc Res] Abstract Stem Cell Recruitment Factors Secreted from Cord Blood-Derived Stem Cells that Are Not Secreted from Mature Endothelial Cells Enhance Wound Healing Researchers examined the wound healing effect of secretory factors released from human cord blood-derived stem cells and human umbilical vascular endothelial cells on cutaneous excisional wound models. [In Vitro Cell Dev Biol Anim] Abstract Brain-Derived Neurotrophic Factor-Modified Umbilical Cord Mesenchymal Stem Cell Transplantation Improves Neurological Deficits in Rats with Traumatic Brain Injury This study explored the effect of brain-derived neurotrophic factor gene-modified umbilical cord mesenchymal stem cell transplantation on neurological functional improvement in rats after brain trauma. [Int J Neurosci] Abstract |