Cord Blood News Volume 5.48 | Dec 5 2013

α-Santalol Inhibits the Angiogenesis and Growth of Human Prostate Tumor Growth by Targeting Vascular Endothelial Growth Factor Receptor 2-Mediated AKT/mTOR/P70S6K Signaling Pathway
Investigators used α-santalol and analyzed its inhibitory effects on human umbilical vein endothelial cells and Prostate tumor cells (PC-3 or LNCaP) in vitro. [Mol Cancer] Full Article

Hepatocyte-Like Cells Derived from Human Amniotic Epithelial Cells Can Be Encapsulated without Loss of Viability or Function In Vitro
Scientists investigated the characteristics of hepatocyte-like cells (HLC) generated from human amniotic epithelial cells and examined the effects of encapsulation on HLC viability, gene expression and function. [Stem Cell Dev] Abstract

Real-Time Monitoring and Control of Soluble Signaling Factors Enables Enhanced Progenitor Cell Outputs from Human Cord Blood Stem Cell Cultures
Researchers describe the development of a microbead-based process control system for the monitoring and control of endogenously produced signaling factors. This monitoring system was incorporated into a fed-batch bioreactor to regulate the accumulation of TGF-β1 in an umbilical cord blood cell expansion system. [Biotechnol Bioeng] Abstract

Hyperglycemia Modifies Energy Metabolism and Reactive Oxygen Species Formation in Endothelial Cells In Vitro
Scientists aimed to describe changes in the mitochondrial metabolism of human umbilical vein endothelial cells treated with high glucose concentrations and to indicate the actual source of reactive oxygen species in these cells. [Arch Biochem Biophys] Abstract

Ghrelin Protects Human Umbilical Vein Endothelial Cells against High Glucose-Induced Apoptosis via mTOR/P70S6K Signaling Pathway
The authors investigated the intracellular mechanisms responsible for anti-apoptotic effect of ghrelin on human umbilical vein endothelial cells (HUVEC). Treatment of HUVEC with ghrelin inhibited high glucose-induced cell apoptosis. [Peptides] Abstract

Reticulocytes from Cryopreserved Erythroblasts Support Plasmodium vivax Infection In Vitro
Researchers report an improved method of hematopoietic stem cell culture for P. vivax infection, which requires less time and produces higher or equivalent percentage of reticulocytes than previously reported systems. Reticulocytes were cultured from cryopreserved erythroblasts that were frozen after 8 day-cultivation of purified CD34+ cells from human umbilical cord blood. [Parasitol Int] Abstract

Modeling Normal and Malignant Human Hematopoiesis In Vivo through Newborn NSG Xenotransplantation
NOD/SCID mice harboring complete null mutation of Il2rg (NSG mice) lack T cells, B cells, and NK cells, and support high levels of engraftment by human cord blood hematopoietic stem cells and acute myeloid leukemia stem cells. [Int J Hematol] Abstract

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bluebird bio Announces First Patient Transplanted in Phase I/II HGB-205 Study for the Treatment of Beta-Thalassemia and Sickle Cell Anemia
bluebird bio, Inc. announced that the first subject with beta-thalassemia major has been enrolled in its Phase I/II HGB-205 study in France and has undergone infusion with bluebird bio’s LentiGlobin drug product in an autologous hematopoietic stem cell transplantation. [bluebird bio, Inc.] Press Release

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Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

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NEW Chief Medical Officer – Novel Therapeutics in Oncology and Autoimmune Disease (Immunomedics, Inc.)

Director – Clinical Immunogenetics Laboratory (Fred Hutchinson Cancer Research Center)

PhD Studentship – iNKT Cells to Prevent Graft versus Host Disease (University of Birmingham)

Postdoctoral Associate – Graft-vs.-Host Disease and Graft-vs.-Leukemia in Mouse Models (Yale University School of Medicine)

Clinical Researcher – Hematopoietic Stem Cell Transplant Program (Northwestern University- Feinberg School of Medicine)

Postdoctoral Research Fellows – Isolation of Stem Cells from Placenta and Amniotic Fluid (Wake Forest Institute for Regenerative Medicine)

Adult Stem Cell Transplant Physician (John Theurer Cancer Center)

Scientist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Research Associate/Scientist – Antibodies Group (STEMCELL Technologies Inc.)

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