Reactive Oxygen Species Induce Matrix Metalloproteinase-12-Dependent Degradation of Collagen 5 and Fibronectin to Promote the Motility of Human Umbilical Cord Derived Mesenchymal Stem Cells The authors investigated the role of hydrogen peroxide in promoting umbilical cord blood derived mesenchymal stem cell motility and its related signaling pathways. [Br J Pharmacol] Abstract Cryopreservation Effects on Wharton’s Jelly Stem Cells Proteome Researchers investigated molecular changes that occur in Wharton’s Jelly stem cells proteome in different experimental conditions: fresh primary cell culture and frozen cell. [Stem Cell Rev] Abstract Incidence and Outcome of Invasive Fungal Diseases after Allogeneic Stem Cell Transplantation: A Prospective Study of the Gruppo Italiano Trapianto Midollo Osseo (GITMO) Epidemiological investigation on invasive fungal diseases (IFD) in allogeneic hematopoietic stem cell transplant may be useful to identify sub-populations who might benefit from targeted strategies. Using logistic regression methods researchers did analyses in order to identify risk factors for proven/probable IFD (PP-IFD) during the early (days 0-40), late (days 41-100) and very late (days 101-365) phases after transplant and to evaluate the impact of PP-IFDs on the one-year overall-survival. [Biol Blood Marrow Transplant] Abstract Effects of THAP11 on Erythroid Differentiation and Megakaryocytic Differentiation of K562 Cells Researchers showed that THAP11 was down-regulated during erythroid differentiation but up-regulated during megakaryocytic differentiation of cord blood CD34+ cells. [PLoS One] Full Article Cell-Based Regenerative Strategies for Treatment of Diabetic Skin Wounds, a Comparative Study between Human Umbilical Cord Blood-Mononuclear Cells and Calves’ Blood Hemodialysate Systemic administration of human umbilical cord blood (HUCB) derived mononuclear cells and topical application of the newly prepared HUCB-hemodialysate (HD) or calves’ blood HD significantly accelerated the rate of diabetic wound healing and would open the possibility of their future use in regenerative medicine. [PLoS One] Full Article Functional Differentiation of Midbrain Neurons from Human Cord Blood-Derived Induced Pluripotent Stem Cells Researchers aimed to establish a differentiation strategy to efficiently generate neurons including dopaminergic cells from human cord blood-derived induced pluripotent stem cells as a juvenescent cell source and prove their functional maturation in vitro. [Stem Cell Res Ther] Abstract | Full Article Aldehyde Dehydrogenase-Bright Cells Correlated with the Colony-Forming Unit-Granulocyte-Macrophage Assay of Thawed Cord Blood Units The number of aldehyde dehydrogenase-bright (ALDHbr) cells has been suggested as a viable marker of hematopoietic stem cell function. Researchers evaluated the suitability of ALDHbr cell analysis in the quality assessment of post-thaw cord blood units. [Transfusion] Abstract Effect of Human Umbilical Cord Blood Mesenchymal Stem Cell Transplantation on Neuronal Metabolites in Ischemic Rabbits Because there is little research on the effects of transplanted stem cells on neuronal metabolites in infarct areas, researchers transplanted human umbilical cord blood mesenchymal stem cells into cerebral ischemic rabbits and examined the neuronal metabolites. [BMC Neurosci] Abstract | Full Article |