IGF2BP1 Expression in Human Mesenchymal Stem Cells Significantly Affects Their Proliferation and Is Under the Epigenetic Control of TET1/2 Demethylases Scientists demonstrated that mesenchymal stem cells of adipose tissue, bone marrow, and umbilical cord blood origin have a differential pattern of IGF2BP1 and TET1/2 expression that could correlate with their proliferation potential. [Stem Cells Dev] Abstract Hypoxia/Hypercapnia-Induced Adaptation Maintains Functional Capacity of Cord Blood Stem and Progenitor Cells at 4°C The authors analyzed the effect of exposure to hypoxic/hypercapnic gas mixture (5% O2/9% CO2) on the maintenance of functional cord blood CD34+ hematopoietic stem and progenitor cells in severe hypothermia (4°C) employing the physiological and proteomic approaches. [J Cell Physiol] Abstract Unmanipulated Haploidentical Transplants Compared with Other Alternative Donors and Matched Sibling Grafts Investigators studied 459 consecutive patients with hematologic malignancies, with a median age of 44 years, grafted from identical siblings, matched unrelated donors, mismatched unrelated donors, unrelated cord blood or HLA haploidentical family donors. [Biol Blood Marrow Transplant] Abstract Human Umbilical Cord-Derived Mesenchymal Stem Cells Do Not Undergo Malignant Transformation during Long-Term Culturing in Serum-Free Medium Data showed that human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) met the International Society for Cellular Therapy standards for conditions of long-term in vitro culturing at P15. Since hUC-MSCs can be safely expanded in vitro and are not susceptible to malignant transformation in serum-free medium, these cells are suitable for cell therapy. [PLoS One] Full Article Long-Term MRI Cell Tracking after Intraventricular Delivery in a Patient with Global Cerebral Ischemia and Prospects for Magnetic Navigation of Stem Cells within the CSF After approval by the Institutional Review Board, an 18-month-old patient, diagnosed as being in a vegetative state due to global cerebral ischemia, underwent cell transplantation to the frontal horn of the lateral ventricle, with umbilical cord blood-derived stem cells labeled with superparamagnetic iron oxide contrast agent. [PLoS One] Full Article Clinical Outcomes of AML Patients Relapsing after Matched-Related Donor and Umbilical Cord Blood Transplantation AML relapse remains the leading cause of transplant failure among Allo-SCT recipients. A single institution study was conducted on 348 patients with AML who received an Allo-SCT from an umbilical cord blood or HLA-matched-related donor. [Bone Marrow Transplant] Abstract Improving Cord Blood Unit Quantity and Quality at King Abdullah International Medical Research Center Cord Blood Bank The authors established a public cord blood bank at a tertiary hospital in Saudi Arabia. They investigated the reasons behind rejecting or not collecting cord blood units over two years and which steps were implemented to improve the number and quality of storable units. [Transfusion] Abstract Generation of a Biomimetic Human Artificial Cornea Model Using Wharton’s Jelly Mesenchymal Stem Cells Scientists have demonstrated for the first time the capability of Human Wharton’s jelly stem cells to differentiate in vitro into cornea epithelial-like cells using a three dimensional model based on fibrin-agarose human bioengineered corneas. [Invest Ophthalmol Vis Sci] Abstract Heading to ISSCR 2014 in Vancouver? Come Visit Connexon Creative at Booth #507 and Enter to Win $100 Amazon Gift Card! |