CSF-1-Dependant Donor-Derived Macrophages Mediate Chronic Graft-versus-Host Disease The authors used multiple murine models of chronic GvHD (cGvHD) to investigate the contribution of macrophage populations in the development of cGvHD. Using an established IL-17-dependent sclerodermatous cGvHD model, they confirmed that macrophages infiltrating the skin are derived from donor bone marrow. [J Clin Invest] Full Article The Effects of 1,25-Dihydroxyvitamin D3 on In Vitro Human NK Cell Development from Hematopoietic Stem Cells Umbilical cord blood CD34+ cells were isolated and cultured in conditions optimal for NK cell differentiation, and varying concentrations of 1,25-Dihydroxyvitamin D3 [1,25(OH)2D3] were administered. At physiological concentrations, 1,25(OH)2D3 impaired NK cell development. [J Immunol] Abstract Improvement of Cardiac Function by Placenta-Derived Mesenchymal Stem Cells Does Not Require Permanent Engraftment and Is Independent of the Insulin Signaling Pathway Investigators evaluated the efficacy of placenta-derived mesenchymal stem cell (MSC) therapy in a mouse model of myocardial infarction. Since MSCs can be obtained from two different regions of the human term placenta (chorionic plate or villi), cells obtained from both these regions were compared so that the best candidate for cell therapy could be selected. [Stem Cell Res Ther] Abstract | Full Article SOX9 as a Predictor for Neurogenesis Potentiality of Amniotic Fluid Stem Cells In an attempt to identify markers of amniotic fluid stem cells (AFSCs) to predict their ability for neurogenesis, the authors performed a two-phase study. In the discovery phase of 23 AFSCs, they tested ZNF521/Zfp521, OCT6, SOX1, SOX2, SOX3, and SOX9 as predictive markers of AFSCs for neural differentiation. The efficacy of these predictive markers was tested in independent sets of 18 AFSCs and 14 dental pulp stem cells. [Stem Cells Transl Med] Abstract Successful Treatment of Severe Immune Hemolytic Anemia after Allogeneic Stem Cell Transplantation with Bortezomib: Report of a Case and Review of Literature Researchers present a case report of immune hemolytic anemia that occurred after allogeneic hematopoietic stem cell transplantation from an ABO major-mismatched, HLA-matched unrelated donor. [Transfusion] Full Article Effect of Preemptive Treatment with Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells on the Development of Renal Ischemia-Reperfusion Injury in Mice Investigators hypothesized that human umbilical cord blood-derived stem cells could suppress the inflammatory response in postischemic kidneys and attenuate early renal injury. [Am J Physiol Renal Physiol] Abstract Isolation and Expansion of Mesenchymal Stromal/Stem Cells from Umbilical Cord under Chemically Defined Conditions To obtain more mesenchymal stromal/stem cells (MSC) from young healthy donors for allogeneic therapy on multiple patients, umbilical cord (UC) seems to be the best alternative. Scientists describe an easy, cost-effective and reproducible protocol of isolation of the MSC from Wharton’s jelly in UC. [Methods Mol Biol] Abstract |