Cord Blood News Volume 6.42 | Oct 30 2014

Modeling De Novo Leukemogenesis from Human Cord Blood with MN1 and NUP98HOXD13
Scientists show that forced expression of MN1 in primitive human cord blood cells maintained on stromal cells in vitro induces a transient, but not serially transplantable, myeloproliferation in engrafted mice. [Blood] Abstract

Human Mesenchymal Stromal Cells Attenuate Graft-versus-Host Disease and Maintain Graft-versus-Leukemia Activity following Experimental Allogeneic Bone Marrow Transplantation
Researchers sought to define the effects and underlying mechanisms of human, marrow-derived mesenchymal stromal cells on graft-versus-host disease and graft-versus-leukemia activity. [Stem Cells] Abstract

Fungal and Viral Infections after Allogeneic Hematopoietic Transplantation from Unrelated Donors in Adults: Improving Outcomes over Time
A total of 434 consecutive unrelated transplants were retrospectively analyzed to compare overall outcomes, incidence and risk factors of severe viral and invasive fungal infections in cord blood versus BM/PB recipients. [Bone Marrow Transplant] Abstract

Expression and Significance of DLL4-Notch Signaling Pathway in the Differentiation of Human Umbilical Cord Derived Mesenchymal Stem Cells into Cardiomyocytes Induced by 5-Azacytidine
hUCMSCs were isolated and purified from the umbilical cords of normal or cesarean term deliveries under sterile conditions. Flow cytometry analysis revealed that CD13, CD29, CD44, CD90, and CD105 were highly expressed on the surface of passage-3 hUCMSCs, but negative for CD31, CD34, CD45, and HLA-DR. [Cell Biochem Biophys] Abstract

The Kinetics of Hematopoietic Niche Cytokines and Their Influence on Mobilization Efficacy and Timing in Patients with Hematological Malignancies
The bone marrow niche functions are modulated by complicated cytokines network. Scientists evaluate the levels of VCAM-1, VEGF, MMP-9 and SDF during mobilization of CD34⁺ cells in patients with hematological malignancies. [J Clin Apher] Abstract

Neural Differentiation of Human Umbilical Cord Matrix-Derived Mesenchymal Cells under Special Culture Conditions
For induction of neural differentiation, human umbilical cord-derived mesenchymal cells were seeded onto sterile glass slides and six various cocktails using a base medium supplemented with 10% FBS, retinoic acid, dimethyl sulfoxide, epidermal growth factor and fibroblast growth factor were used to compare their effect on neuronal, astrocyte and oligodendrocyte differentiation. [Cytotechnology] Abstract

Evaluation of Ultrasmall Superparamagnetic Iron Oxide Contrast Agent Labeling of Equine Cord Blood and Bone Marrow Mesenchymal Stromal Cells
Researchers evaluated the efficacy and effects of labeling equine umbilical cord blood- and bone marrow-derived multipotent mesenchymal stromal cells (MSCs) with an ultrasmall superparamagnetic iron oxide contrast agent and the detection of labeled MSCs by use of MRI. [Am J Vet Res] Abstract

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The Leukemia & Lymphoma Society Awards $15.6 Million to Help Advance Research from Lab to Clinic
The Leukemia & Lymphoma Society is awarding $15.6 million in academic grants to 26 scientists who have proposed innovative laboratory research that shows promise in leading to new treatments for blood cancer patients. [The Leukemia & Lymphoma Society] Press Release

Americord Launches Revolutionary Stem Cell Collection Process
Americord Registry announced the launch of Cord Blood 2.0™, its innovative cord blood banking system that can collect and preserve up to twice as many stem cells as traditional cord blood collections. [Americord Registry (PR Newswire Association LLC)] Press Release

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Postdoctoral Position – NK Cell and Leukemia Research (Children’s Hospital Los Angeles)

Postdoctoral Fellow – Hematopoiesis and Hematologic Malignancy (University of Michigan)

Postdoctoral Position – Hematopoietic Stem and Progenitor Cell Biology (Lund University)

Quality Improvement Coordinator – Regenerative Medicine (The University of Texas Health Science Center at Houston)

Postdoctoral Position – Molecular Mechanisms of Hematopoiesis and Blood Disorders (St. Jude Children’s Research Hospital)

Postdoctoral Positions – Models of Myelodysplastic Syndromes, Leukemia and Inherited Bone Marrow Failure (Icahn School of Medicine at Mount Sinai)

Faculty Positions – Stem Cells and Regenerative Medicine (Baylor College of Medicine)

Postdoctoral Fellow – Hematopoietic Stem Cells and Signaling Transduction (University of Pennsylvania)

Postdoctoral Positions – Hematopoietic and Induced Pluripotent Stem Cells (Indiana University School of Medicine)

Cord Tissue Processing Technician (Cord Blood Registry)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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