Cord Blood News Volume 6.47 | Dec 4 2014

A Survey on Unmanipulated Haploidentical Hematopoietic Stem Cell Transplantation in Adults with Acute Leukemia
Investigators analyzed the outcome of 229 adult patients with de novo acute leukemia, who received an unmanipulated haploidentical transplant as their first allogeneic hematopoietic stem cell transplantation. [Leukemia] Abstract

Intranasal versus Intraperitoneal Delivery of Human Umbilical Cord Tissue-Derived Cultured Mesenchymal Stromal Cells in a Murine Model of Neonatal Lung Injury
Scientists studied the morphologic and functional effects of intranasal versus intraperitoneal mesenchymal stromal cell administration in a rodent model of neonatal lung injury. [Am J Pathol] Abstract

Umbilical Cord Mesenchymal Stromal Cells Affected by Gestational Diabetes Mellitus Display Premature Aging and Mitochondrial Dysfunction
Scientists compared the basic properties of human umbilical cord mesenchymal stromal cells obtained from gestational diabetes mellitus patients and normal pregnant women. [Stem Cells Dev] Abstract

Post-Thaw Non-Cultured and Post-Thaw Cultured Equine Cord Blood Mesenchymal Stromal Cells Equally Suppress Lymphocyte Proliferation In Vitro
Investigators hypothesized that in vitro there is no difference in lymphocyte suppression potential between quick-thawed cryopreserved equine cord blood mesenchymal stromal cells (MSC) immediately included in mixed lymphocyte reaction (MLR) and the same MSC allowed post-thaw culture time prior to inclusion in MLR. [PLoS One] Full Article

Treosulfan Based Reduced Toxicity Conditioning followed by Allogeneic Stem Cell Transplantation in Patients with Myelofibrosis
Researchers report 14 patients affected by myelofibrosis with a median age of 57 years receiving a treosulfan-fludarabine based reduced toxicity conditioning. Patients received a stem cell transplantation from an HLA identical or matched unrelated donor. [Hematol Oncol] Abstract

Therapeutic Effect of Human Umbilical Cord Mesenchymal Stem Cells Modified by Angiotensin-Converting Enzyme 2 Gene on Bleomycin-Induced Lung Fibrosis Injury
Investigators evaluated the therapeutic effects of human umbilical cord mesenchymal stem cells in the presence of angiotensinconverting enzyme 2 gene on bleomycin induced lung injury and pulmonary fibrosis in mice. [Mol Med Rep] Abstract | Download Full Article

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CPRIT Awards UTSW Faculty $22.5 Million for Recruitment and Research in Liver Cancer, Leukemia, and Immunotherapy
UT Southwestern Medical Center faculty was awarded seven grants totaling more than $22 million from the Cancer Prevention and Research Institute of Texas (CPRIT) for investigations into leukemia, liver cancer, and immunotherapy, as well as to recruit new faculty. [UT Southwestern Medical Center] Press Release

Actinium Receives Orphan-Drug Designation from FDA for Actimab-A in the Treatment of Newly Diagnosed Acute Myeloid Leukemia in Elderly Patients
Actinium Pharmaceuticals, Inc. announced that the US Food and Drug Administration (FDA) has granted orphan-drug designation for Actimab-A, an alpha radiolabeled antibody being developed for newly diagnosed AML in patients over the age of 60. [Actinium Pharmaceuticals, Inc.] Press Release

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NEW Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Mesenchymal Stem Cell (MSC) Laboratory Technician (California Cryobank)

Clinical Laboratory Scientist – Umbilical Cord Blood Processing (California Cryobank)

PhD Student – Department of Hematopoiesis (Sanquin)

Head of Cellular and Molecular Therapies Laboratory (NHS Blood & Transplant)

Postdoctoral Fellow – Stem Cell Biology Gene Expression and Regulation (The University of Texas Medical School at Houston)

Postdoctoral Fellow – Molecular Mechanisms Regulating Human Hematopoietic Specification (Washington University School of Medicine)

Quality Improvement Coordinator – Regenerative Medicine (The University of Texas Health Science Center at Houston)

Cord Tissue Processing Technician (Cord Blood Registry)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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