Human Placenta-Derived Multipotent Cells (hPDMCs) Modulate Cardiac Injury: From Bench to Small & Large Animal Myocardial Ischemia Studies The authors report that hPDMCs can modulate cardiac injury in small and large animal models of myocardial ischemia, and elucidate the mechanisms involved. They found that hPDMCs can undergo in vitro cardiomyogenic differentiation when co-cultured with mouse neonatal cardiomyocytes. [Cell Transplant] Full Article Mycophenolate Based GvHD Prophylaxis Is Not Inferior to Methotrexate in Myeloablative Related Donor Stem Cell Transplantation Investigators retrospectively reviewed 242 patients who received related donor myeloablative peripheral blood hematopoietic cell transplantation. They compared patients who received mycophenolate/cyclosporine (CSA), to historical controls who received methotrexate/CSA. [Am J Hematol] Abstract Cord Blood Collection and Banking from a Population with Highly Diverse Geographic Origins Increase HLA Diversity in the Registry and Do Not Lower the Proportion of Validated Cord Blood Units: Experience of the Marseille Cord Blood Bank Scientists compared biological characteristics of 106 cord blood units (CBU) disqualified for total nucleated cell count (dCBU) and 136 qualified CBU in relation to registry enrichment and haplotype origin A high proportion of both dCBU and CBU had at least one non-European haplotype and enrich CB and unrelated donor registries to a higher extent than those with two European haplotypes. [Bone Marrow Transplant] Abstract Efficiency of Allogeneic Hematopoietic SCT from HLA Fully-Matched Non-Sibling Relatives: A New Prospect of Exploiting Extended Family Search Researchers retrospectively studied the hematopoietic SCT outcome in patients with fully-matched non-sibling donors. In 83 patients, full chimerism and in 17 patients, mixed chimerism was achieved. Acute GvHD grade II-IV appeared in 36 patients. [Bone Marrow Transplant] Abstract Absolute Lymphocyte Count Recovery after Allogeneic Hematopoietic Stem Cell Transplantation Predicts Clinical Outcome To determine the impact of absolute lymphocyte count recovery on clinical outcomes investigators conducted a retrospective study of 1,109 adult patients who underwent a first allogeneic hematopoietic stem cell transplantation, excluding patients who died or relapsed before day 30. [Biol Blood Marrow Transplant] Abstract Hematopoietic Recovery of Acute Radiation Syndrome by Human Superoxide Dismutase-Expressing Umbilical Cord Mesenchymal Stromal Cells Investigators examined an alternative therapeutic approach to acute radiation syndrome with the use of human extracellular superoxide dismutase-modified umbilical cord mesenchymal stromal cells. [Cytotherapy] Abstract Allogeneic Hematopoietic Stem Cell Transplantation for Adult Patients with Mixed Phenotype Acute Leukemia: Results of a Matched-Pair Analysis Researchers retrospectively assessed the efficacy of allogeneic stem cell transplantation for mixed phenotype acute leukemia (MPAL). Eighteen patients with MPAL were identified from the transplant outcome database of KSGCT. [Eur J Haematol] Abstract |