Cord Blood News Volume 7.05 | Feb 12 2015

No Synergistic Effect of Co-Transplantation of MSC and Ex Vivo TPO Expanded CD34⁺ Cord Blood Cells on Platelet Recovery and Bone Marrow Engraftment in NOD SCID Mice
After cord blood transplantation, early platelet recovery in immune deficient mice is obtained by expansion of cord blood (CB) CD34⁺ cells with TPO as single growth factor. Moreover, improvement of hematopoietic engraftment has been shown by co-transplantation of mesenchymal stem cells (MSC). Scientists investigated whether a combination of both approaches would further enhance the outcome of CB transplantation in NOD SCID mice. [Stem Cells Dev] Abstract

Transplantation of Human Placenta-Derived Multipotent Stem Cells Reduces Ischemic Brain Injury in Adult Rats
Investigators examined the protective effect of human placenta derived multipotent stem cell transplants in a rodent model of stroke. Adult male Sprague-Dawley rats were anesthetized. [Cell Transplant] Full Article

Alteration of Histone Acetylation Pattern during Long-Term Serum-Free Culture Conditions of Human Fetal Placental Mesenchymal Stem Cells
Alterations to histone acetylation and consequence on the expression pattern of mesenchymal stem cells derived from placenta of fetal origin following in vitro propagation under serum-free conditions were explored. [PLoS One] Full Article

Sorafenib Treatment following Hematopoietic Stem Cell Transplant in Pediatric FLT3/ITD Acute Myeloid Leukemia
Investigators conducted a retrospective study of 15 pediatric patients with FLT3/ITD⁺ acute myeloid leukemia treated with sorafenib within 18 months after receiving hematopoietic stem cell transplantation. [Pediatr Blood Cancer] Abstract

Allogeneic Donor Availability for Hematopoietic Stem Cell Transplantation in Children with Sickle Cell Disease
Searches for 85 patients with sickle cell disease without matched sibling donors from 2009-2013 using modern techniques showed potential match probabilities of 20% for 8/8 HLA-matched unrelated donors, 84% for 7/8 donors, and 97% for two 4-6/6 umbilical cord blood samples suitable for ex-vivo expanded/double cord transplant. [Pediatr Blood Cancer] Abstract

Third Allogeneic Stem Cell Transplantation (SCT) Using Unrelated Cord Blood for Relapsed Acute Leukemia after Second Allogeneic SCT
Investigators analyzed the results of third allogeneic stem cell transplantation using single-unit unrelated cord blood in seven adult patients with relapsed acute leukemia after second allogeneic SCT. [Int J Hematol] Abstract

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Three USC Researchers Win $4.3 Million in Awards from California’s Stem Cell Agency
Three scientists from Keck Medicine of USC have won grants exceeding $4.3 million from the California Institute for Regenerative Medicine for research that includes creating a temporary liver for patients, finding novel ways to treat immune disorders and blood diseases, and developing new animal models for heart failure, diabetes and neurodegenerative diseases. [University of Southern California] Press Release

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Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Senior Process Development Engineer (Sangamo BioSciences, Inc.)

Director – Vector Production (Sangamo BioSciences, Inc.)

Postdoctoral Fellow – Hematology and Oncology (Guangzhou Women and Children’s Medical Center)

Research Associate – Generating Mature Blood Cells from Induced Pluripotent Stem Cells (University of Cambridge)

Postdoctoral Fellow – Targeted Gene Editing in Hematopoietic Stem Cells (University Medical Center Freiburg)

Principal Investigator – Stem Cell Biology, Hematopoiesis and Hematology (Guangzhou Women and Children’s Medical Center)

PhD Studentships – Expansion of Umbilical Cord Blood Stem Cells (University College London)

Cord Tissue Processing Technician (Cord Blood Registry)

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