Cord Blood News Volume 7.14 | Apr 16 2015

Donor CD4 T Cell Diversity Determines Virus Reactivation in Patients after HLA-Matched Allogeneic Stem Cell Transplantation
Scientists studied the T cell receptor beta gene rearrangements of flow cytometry-sorted CD4⁺ and CD8⁺ T cells from the peripheral blood of 23 allogeneic donors before granulocyte colony-stimulating factor administration and on the day of apheresis. [Am J Transplant] Full Article

Treatment of Collagen-Induced Arthritis Using Immune Modulatory Properties of Human Mesenchymal Stem Cells
Researchers investigated the potential therapeutic effects of human bone marrow-, adipose tissue-, and cord blood-derived mesenchymal stem cells (MSCs) in an experimental animal model of rheumatoid arthritis, and explored the mechanism underlying immune modulation by MSCs. [Cell Transplant] Full Article

Leukemia Cell Mobilization with G-CSF plus Plerixafor during Busulfan-Fludarabine Conditioning for Allogeneic Stem Cell Transplantation
Investigators compared the clinical effects and outcomes of AML/myelodysplastic syndrome study patients with 164 patients from a historical data set who received busulfan-fludarabine alone before allogeneic stem cell transplant by stratifying on cytogenetics and disease status to correct for bias. [Bone Marrow Transplant] Abstract

Autologous Stem Cell Transplantation versus Novel Drugs or Conventional Chemotherapy for Patients with Relapsed Multiple Myeloma after Previous ASCT
Researchers retrospectively studied the outcome of second-line treatment in multiple myeloma patients from the Nordic countries with relapse after first-line high-dose therapy and autologous stem cell transplantation (ASCT). [Bone Marrow Transplant] Abstract

Experience with Alemtuzumab Fludarabine, and Melphalan Reduced Intensity Conditioning Hematopoietic Cell Transplantation in over 200 Patients with Non-Malignant Diseases Reveals Good Outcomes and that Risk of Mixed Chimerism Depends on Underlying Disease, Stem Cell Source, and Alemtuzumab Regimen
Investigators conducted a retrospective study of 206 patients with metabolic diseases, non-Fanconi anemia marrow failure disorders, and primary immune deficiencies who underwent 210 consecutive RIC HCT procedures at Cincinnati Children’s Hospital. [Biol Blood Marrow Transplant] Abstract

Cell Type-Dependent Variation in Paracrine Potency Determines Therapeutic Efficacy against Neonatal Hyperoxic Lung Injury
Scientists determined the optimal cell type for transplantation to protect against neonatal hyperoxic lung injury. The in vitro and in vivo therapeutic efficacies and paracrine potencies of human umbilical cord blood-derived mesenchymal stromal cells, human adipose tissue-derived mesenchymal stromal cells and human umbilical cord blood mononuclear cells were compared. [Cytotherapy] Full Article

Outcomes of Mismatched and Unrelated Donor Hematopoietic Stem Cell Transplantation in Fanconi Anemia Conditioned with Chemotherapy Only
Investigators present their experience with 17 Fanconi anemia patients who completed mismatched related or unrelated donor hematopoietic stem cell transplantation using a non-radiation fludarabine-based preparative regimen. [Ann Hematol] Abstract

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Cardio3 BioSciences Enrolls First Patient in Phase I Trial for NKG2D CAR T-Cell
Cardio3 BioSciences announced the enrollment of the first patient in a Phase I clinical trial evaluating the Company’s lead CAR T-Cell therapy, NKG2D CAR T-Cell, in blood cancer patients with acute myeloid leukemia or multiple myeloma. [Cardio3 BioSciences S.A.] Press Release

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NEW Postdoctoral Fellow – Hematopoietic Stem Cell Biology (University of Leuven)

Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Postdoctoral Fellow – Hematopoietic Stem Cell Research (Lund University)

Postdoctoral Research Fellow – Stem Cell/Hematopoiesis Research (BloodCenter of Wisconsin)

Research Associate – Hematopoietic and Leukemic Stem Cells (Shanghai Jiao-Tong University School of Medicine)

Postdoctoral Fellows – Leukemia Research and Stem Cell Biology (Josep Carreras Leukemia Research Institute)

PhD Studentships – Expansion of Umbilical Cord Blood Stem Cells (University College London)

Cord Tissue Processing Technician (Cord Blood Registry)

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