Cord Blood News Volume 7.18 | May 14 2015

Recipient Expression of Ligands for Donor Inhibitory KIRs Enhances NK-Cell Function, to Control Leukemic Relapse after Haploidentical Transplantation
Researchers compared the functionality of reconstituting natural killer (NK) cells, based on CD107α expression and interferon-γsecretion, in a cohort of 29 patients that expressed or lacked class-I HLAs for donor inhibitory KIRs following T-cell-replete haploidentical stem cell transplantation. [Eur J Immunol] Abstract

Age-Related Increase of EED Expression in Early Hematopoietic Progenitor Cells Is Associated with Global Increase of the Histone Modification H3K27me3
In vitro differentiation of EED-transfected neonatal hematopoietic stem and progenitor cells revealed delayed differentiation towards the lymphoid lineage and aberrant expression of the myelopoietic marker CD14, suggesting that EED affects the lymphoid versus myeloid decision processes within the lymphomyeloid lineage. [Stem Cells Dev] Abstract

Improved Neurological Outcome by Intramuscular Injection of Human Amniotic Fluid Derived Stem Cells in a Muscle Denervation Model
Researchers assessed the outcome of neurological function by intramuscular injection of human amniotic derived stem cells in a muscle denervation and nerve anastomosis model. [PLoS One] Full Article

Outcomes of Cord Blood Transplantation Using Reduced Intensity Conditioning for Chronic Lymphocytic Leukemia: A Study on Behalf of Eurocord and Cord Blood Committee of Cellular Therapy and Immunobiology Working Party (CTIWP), Chronic Malignancies Working Party (CMWP) of the EBMT and the Societé Française de Greffe de Moelle et Therapie Cellulaire (SFGM-TC)
Researchers analyzed outcomes of 68 patients with poor risk chronic lymphocytic leukemia/small lymphocytic lymphoma who underwent reduced intensity umbilical cord blood transplantation from 2004-2012. [Biol Blood Marrow Transplant] Abstract

Rapid and Efficient Generation of Transgene-Free iPSC from a Small Volume of Cryopreserved Blood
The authors demonstrated that peripheral blood can be utilized for medium-throughput induced pluripotent stem cell (iPSC) production without the need to maintain cell culture prior to reprogramming induction. Cell reprogramming can also be accomplished with as little as 3000 previously cryopreserved cord blood cells under feeder-free and chemically defined xeno-free conditions. [Stem Cell Rev] Full Article

Efficacy and Safety of Cord Blood-Derived Cytokine-Induced Killer Cells in Treatment of Patients with Malignancies
After the infusion of cord blood-cytokine-induced killer cells, the subsets of CD3⁺CD4⁺ T lymphocytes and CD3^–CD56⁺ T cells in the peripheral blood were significantly increased compared with those before the therapy. [Cytotherapy] Abstract

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Pluristem Granted European Patent for Use of Cells to Help Treat Damaged Bone Marrow
Pluristem Therapeutics Inc. announced that it has been issued Patent No. EP2366775B1, titled “Methods for Cell Expansion and Uses of Cells and Conditioned Media Produced Thereby for Therapy”, by the European Patent Office. Pluristem’s therapeutic cells are designed to promote the success of hematopoietic stem cell transplantation, which is used to treat patients with dysfunctional bone marrow. [Pluristem Therapeutics Inc.] Press Release

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Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

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Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Postdoctoral Researcher – Hematopoietic Stem Cell Physiology and Pathophysiology (International Research Center for Medical Sciences)

Postdoctoral Associate – Epigenetic Regulation of Normal and Leukemic Stem Cells (Sanford-Burnham Medical Research Institute)

Postdoctoral Fellow – Hematopoietic Stem Cell Biology (University of Leuven)

Postdoctoral Fellow – Hematopoietic Stem Cell Research (Lund University)

Postdoctoral Research Fellow – Stem Cell/Hematopoiesis Research (BloodCenter of Wisconsin)

Postdoctoral Fellows – Leukemia Research and Stem Cell Biology (Josep Carreras Leukemia Research Institute)

Cord Tissue Processing Technician (Cord Blood Registry)

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