Cord Blood News Volume 7.32 | Aug 20 2015

Allogeneic Hematopoietic Stem Cell Transplantation for Mitochondrial Neurogastrointestinal Encephalomyopathy
Investigators conducted a retrospective analysis of all known patients suffering from mitochondrial neurogastrointestinal encephalomyopathy who underwent allogeneic hematopoietic stem cell transplantation between 2005 and 2011. [Brain] Abstract

Transplantation of Placenta-Derived Mesenchymal Stem Cells Enhances Angiogenesis after Ischemic Limb Injury in Mice
The authors showed that placenta-derived mesenchymal stem cell treatment significantly enhanced microvessel density, improved blood perfusion and diminished pathologies in ischemic mouse hindlimbs as compared to those in the control group. [J Cell Mol Med] Abstract | Full Article

Enhancement of the Immunoregulatory Potency of Mesenchymal Stromal Cells by Treatment with Immunosuppressive Drugs
With the use of a pre-clinical model of acute graft-versus-host disease, scientists demonstrated that a low dose of rapamycin-treated but not untreated umbilical cord–derived mesenchymal stromal cells significantly inhibited the onset of disease. [Cytotherapy] Abstract | Full Article

A Simple, Rapid, and Efficient Method for Isolating Mesenchymal Stem Cells from the Entire Umbilical Cord
Scientists present a modulated explant/enzyme method to isolate the maximum number of mesenchymal stem cells from the entire umbilical cord. [Cell Transplant] Abstract

The Targeted Inhibitory Effects of Human Amniotic Fluid Stem Cells Carrying CXCR4 Promoter and DAL-1 on Non-Small Cell Lung Carcinoma Growth
Investigators determined the targeted effects of human amniotic fluid stem cells carrying CXCR4 promoter driven conditionally replicable adenovirus vector over-expressing differentially expressed in adenocarcinoma of the lung-1 (DAL-1) on non-small cell lung carcinoma growth. [Gene Ther] Abstract

Intranasal Administration of Human Umbilical Cord Mesenchymal Stem Cells-Conditioned Medium Enhances Vascular Remodeling after Stroke
Researchers investigated whether intranasal administration of human umbilical cord mesenchymal stem cells-condition medium has the therapeutic effects in rats after stroke. [Brain Res] Abstract

Effects of Magnesium Degradation Products on Mesenchymal Stem Cell Fate and Osteoblastogenesis
To mimic the in vivo effects of the degradation of magnesium-based implants on mesenchymal stem cell differentiation during bone remodeling, non-hematopoietic multipotent fetal progenitor cells, i.e., human umbilical cord perivascular cells, were cultured for up to three weeks with or without osteoblastic differentiating media and with or without magnesium extract [Gene] Abstract

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Phase II Study of Venetoclax in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia with 17p Deletion Meets Primary Endpoint
AbbVie announced that a Phase II trial of its investigational medicine venetoclax met its primary endpoint of achieving overall response rates in patients with relapsed/refractory or previously untreated chronic lymphocytic leukemia with 17p deletion, according to an independent review analysis. [AbbView Inc.] Press Release

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Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Postdoctoral Fellowship – Leukemia (Stanford University School of Medicine)

Laboratory Technologist – Cord Blood and Cord Tissue Bank (Texas Stem Cell)

Postdoctoral Position – Hematopoietic Stem and Progenitor Cell Assays (Weill Cornell Medical School)

Postdoctoral Fellow – Hematopoietic Regeneration and Myeloid Malignancies (Weill-Cornell Medical College)

Research Associate – Cell Biology (Editas Medicine)

Independent Junior Group Leader – Lymphopoiesis or Gene Regulation/Nuclear Architecture in the Hematopoietic System (Max-Planck-Institute)

Postdoctoral Fellow – Immune Reconstitution in Hematopoietic Stem Cell Transplantation (Stanford University)

Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

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