Anti-Aging Effect of Transplanted Amniotic Membrane Mesenchymal Stem Cells in a Premature Aging Model of Bmi-1 Deficiency To determine whether transplanted amniotic membrane mesenchymal stem cells (AMSCs) ameliorated the premature senescent phenotype of Bmi-1-deficient mice, postnatal 2-day-old Bmi-1−/− mice were injected intraperitoneally with the second-passage AMSCs from amniotic membranes of β-galactosidase transgenic mice or wild-type mice labeled with DiI. [Sci Rep] Full Article Human Umbilical Cord Matrix-Derived Stem Cells Exert Trophic Effects on β-Cell Survival in Diabetic Rats and Isolated Islets Scientists tested whether umbilical cord matrix-derived stem cells (uMSCs) could exert direct trophic effects on β-cells. Infusion of uMSCs into chemically induced diabetic rats prevented hyperglycemic progression with a parallel preservation of islet size and cellularity, demonstrating the protective effect of uMSCs on β-cells. [Dis Model Mech] Abstract Impact of MRD and TKI on Allogeneic Hematopoietic Cell Transplantation for Ph+ALL: A Study from the Adult ALL WG of the JSHCT The authors retrospectively analyzed data from a registry database for 432 adult Ph-positive ALL (Ph+ALL) patients in first CR who received pre-transplant tyrosine kinase inhibitor administration. [Bone Marrow Transplant] Abstract Should Busulfan Therapeutic Range Be Narrowed in Pediatrics? Experience from a Large Cohort of Hematopoietic Stem Cell Transplant Children Researchers report their experience with busulfan therapeutic drug monitoring in a large cohort of children. They investigated the relevance of using a more restricted therapeutic range and investigated the association between busulfan therapeutic range and clinical outcome. [Bone Marrow Transplant] Abstract Magnetic Resonance Detection of CD34+ Cells from Umbilical Cord Blood Using a 19F Label Researchers showed sufficient intracellular labeling of umbilical cord blood-derived CD34+ cells, with 19F-containing PLGA nanoparticles which were detectable with both flow cytometry and magnetic resonance spectroscopy. [PLoS One] Full Article Hypoxic Preconditioning Increases Survival and Pro-Angiogenic Capacity of Human Cord Blood Mesenchymal Stromal Cells In Vitro Scientists developed a specific hypoxic preconditioning protocol and investigated its anti-apoptotic and pro-angiogenic effects on cord blood mesenchymal stromal cells undergoing simulated ischemia in vitro by subjecting them to hypoxia and nutrient deprivation with or without preceding hypoxic preconditioning. [PLoS One] Full Article European Society for Blood and Marrow Transplantation Analysis of Treosulfan Conditioning before Hematopoietic Stem Cell Transplantation in Children and Adolescents with Hematological Malignancies Investigators performed a retrospective analysis of 193 children with hematological malignancies undergoing allogeneic hematopoietic stem cell transplantation following treosulfan. [Pediatr Blood Cancer] Abstract |