Extensive Nuclear Reprogramming Underlies Lineage Conversion into Functional Trophoblast Stem-Like Cells Researchers showed that transient expression of Gata3, Eomes, and Tfap2c in mouse fibroblasts induces stable, transgene-independent trophoblast stem-like cells. [Cell Stem Cell] Abstract | Graphical Abstract Direct Comparison of Wharton Jelly and Bone Marrow Derived Mesenchymal Stromal Cells to Enhance Engraftment of Cord Blood CD34+ Transplants Investigators evaluated the ability of Wharton’s jelly mesenchymal stromal cells (WJ MSC) to enhance hematopoietic stem and progenitor cells engraftment. They compared cultured human WJ MSC with human bone marrow-derived MSC for in vitro marker expression, immunomodulatory capacity and differentiation into three mesenchymal lineages. [Stem Cells Dev] Abstract Umbilical Cord Blood Transplantation Outcomes in Acute Myelogenous Leukemia/Myelodysplastic Syndromes Patients ≥70 Years Old Researchers retrospectively investigated the outcomes of umbilical cord blood transplantation after a reduced intensity conditioning regimen in patients with myelodysplastic syndrome and acute myelogenous leukemia ≥ 70 years. [Biol Blood Marrow Transplant] Abstract Umbilical Cord Blood-Derived CD11c+ Dendritic Cells Could Serve as an Alternative Allogeneic Source of Dendritic Cells for Cancer Immunotherapy Scientists compared CD11c+ umbilical cord blood-dendritic cells (DCs)/cytotoxic T lymphocytes (CTLs) with monocyte DCs/CTLs, using various parameters. [Stem Cell Res Ther] Full Article Preterm Cord Blood Contains a Higher Proportion of Immature Hematopoietic Progenitors Compared to Term Samples Researchers studied the functional properties of the umbilical cord blood progenitor cells collected from term and preterm neonates to establish whether quantitative and/or qualitative differences exist between the two groups. [PLoS One] Full Article Bio-Distribution of Infused Human Umbilical Cord Blood Cells in Alzheimer’s Disease-Like Murine Model Researchers followed the bioavailability of human umbilical cord blood cells in Alzheimer’s disease-like transgenic PSAPP mice and non-transgenic Sprague-Dawley rats. [Cell Transplant] Abstract Mesenchymal Stem Cells of Different Origin: Comparative Evaluation of Proliferative Capacity, Telomere Length and Pluripotency Marker Expression The authors characterized and compared proliferation, differentiation, telomere length and pluripotency marker expression in mesenchymal stem cells of various origins. [Life Sci] Abstract Adenoviral Vector Carrying Glial Cell-Derived Neurotrophic Factor for Direct Gene Therapy in Comparison with Human Umbilical Cord Blood Cell-Mediated Therapy of Spinal Cord Injury in Rat Scientists evaluated the treatment of spinal cord injury with glial cell-derived neurotrophic factor delivered using an adenoviral vector in comparison with treatment performed using human umbilical cord blood mononuclear cells-transduced with an adenoviral vector carrying the GDNF gene in rat. [Spinal Cord] Abstract |