Unrelated Cord Blood Transplantation for Adult Patients with Acute Myeloid Leukemia: Higher Incidence of Acute Graft-Versus-Host Disease and Lower Survival in Male Patients Transplanted with Female Unrelated Cord Blood- A Report from Eurocord, the Acute Leukemia Working Party, and the Cord Blood Committee of the Cellular Therapy and Immunobiology Working Party of the European Group for Blood and Marrow Transplantation Researchers compared transplantation outcomes in male patients given female unrelated cord blood (UCB) versus other gender combinations. They suggest that male patients transplanted with female UCB might have higher risk of acute graft-versus-host disease and of nonrelapse mortality leading to worse leukemia-free and overall survival. [J Hematol Oncol] Full Article Transplantation of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells Highly Expressing TGFβ Receptors in a Rabbit Model of Disc Degeneration Investigators evaluated the effectiveness of a cross-linked hyaluronic acid scaffold loaded with human Wharton’s jelly-derived mesenchymal stem cells, according to their expression levels of transforming growth factor-β receptor (TβR) I/activin-like kinase receptor 5 and TβRII, for intervertebral disc regeneration in a rabbit model. [Stem Cell Res Ther] Full Article A Novel Method to Expand Large Numbers of CD56+ Natural Killer Cells from a Minute Fraction of Selectively Accessed Cryopreserved Cord Blood for Immunotherapy after Transplantation Researchers developed and optimized a strategy to selectively access a small fraction from cryopreserved umbilical cord blood and showed that large numbers of CD56+ cells can be expanded from this selectively accessed fraction. [Cytotherapy] Abstract A Unique Expression of Keratin 14 in a Subset of Trophoblast Cells Researchers characterized the presence of different keratins in human trophoblast cells and vimentin in stromal cells. Using immunohistochemistry on term placental sections, their results showed that vimentin is solely expressed in stromal-mesenchymal cells while keratins 5, 7, 8, 14 and 19 are expressed in trophoblast cells. [PLoS One] Full Article Serial Investigation of PTPN11 Mutation in Nonhematopoietic Tissues in a Patient with Juvenile Myelomonocytic Leukemia Who Was Treated with Unrelated Cord Blood Transplantation The authors described a juvenile myelomonocytic leukemia case with a typical PTPN11 mutation at different allele frequencies in the bone marrow mononuclear cells, buccal smear cells, and fingernails at diagnosis, which was suggestive of PTPN11 somatic mosaicism; however, the PTPN11 mutation in the buccal smear cells and fingernails was lost after unrelated cord blood transplantation. [Int J Hematol] Abstract Construction of Recombinant Adenovirus Containing Picorna-Viral 2A-Peptide Sequence for the Co-Expression of Neuro-Protective Growth Factors in Human Umbilical Cord Blood Cells Researchers described a strategy for adeno-viral co-expression of vascular endothelial growth factor and fibroblast growth factor 2 interconnected through picorna-viral 2A-amino-acid sequence in transfected human umbilical cord blood mononuclear cells. [Spinal Cord] Abstract | Press Release In Vitro Differentiation Process of Human Wharton’s Jelly Mesenchymal Stem Cells to Male Germ Cells in the Presence of Gonadal and Non-Gonadal Conditioned Media with Retinoic Acid Researchers determined under which conditions human umbilical Wharton’s jelly-derived mesenchymal stem cells (HWJMSCs) could form male germ cells in vitro. HWJMSCs were differentiated to male germ cells under a mixture of bone morphogenetic protein-4 and testicular and placental culture condition medium followed by retinoic acid for 21 days. [In Vitro Cell Dev Biol Anim] Abstract |