High-Dose CD20-Targeted Radioimmunotherapy-Based Autologous Transplantation Improves Outcomes for Persistent Mantle Cell Lymphoma Researchers assessed 162 consecutive patients with mantle cell lymphoma at their center undergoing autologous stem cell transplant following high-dose radioimmunotherapy-based or standard conditioning. [Br J Haematol] Abstract Comparative Analysis of Human Mesenchymal Stem Cells Derived from Bone Marrow, Placenta and Adipose Tissue as Sources of Cell Therapy Scientists characterized mesenchymal stem cells from different sources, including human bone marrow, placenta, and adipose tissue, in terms of the phenotype, surface antigen expression, differentiation ability, proteome reference map and blood flow recovery in a hindlimb ischemic disease model. [J Cell Biochem] Abstract Cerebral Vasculitis in X-Linked Lymphoproliferative Disease Cured by Matched Unrelated Cord Blood Transplant A nine-year old boy initially presented aged five years with a restrictive joint disease. A diagnosis of X-linked lymphoproliferative disease was made, based on flow cytometric analysis and the identification of a novel mutation in SH2D1A, c.96G>C. He underwent a reduced intensity unrelated umbilical cord blood transplant, but failed to engraft. [J Clin Immunol] Abstract Optimal Timing of Mesenchymal Stem Cell Therapy for Neonatal Intraventricular Hemorrhage The authors showed that intraventricular transplantation of human umbilical cord blood-derived mesenchymal stem cells (MSC) significantly attenuated posthemorrhagic hydrocephalus and brain injury after severe intraventricular hemorrhage (IVH) in newborn rat pups. They aimed to optimize the timing of MSC transplantation for severe IVH. [Cell Transplant] Abstract Cord Blood Processing by a Novel Filtration System Investigators describe development and characterization of a novel filter device aimed at allowing cord blood processing, using gentle gravity-led flow. [Cell Prolif] Full Article Mechanism Study for Hypoxia Induced Differentiation of Insulin-Producing Cells from Umbilical Cord Blood-Derived Mesenchymal Stem Cells Scientists found that hypoxia induced c-MET elevation efficiently initiated the early stage differentiation of insulin-producing cells (IPCs) from mesenchymal stem cells, and hepatocyte growth factor improved the full differentiation of IPCs by inducing the expression of NGN3. [Biochem Biophys Res Commun] Abstract Outcome of Reduced-Intensity Allogeneic Hematopoietic Stem Cell Transplantation for Multiple Myeloma Researchers evaluated single-institute outcomes of allogeneic hematopoietic stem cell transplantation with a reduced-intensity conditioning regimen consisting of fludarabine and melphalan for multiple myeloma. [Int J Hematol] Abstract Adenoviral Vector Carrying Glial Cell-Derived Neurotrophic Factor for Direct Gene Therapy in Comparison with Human Umbilical Cord Blood Cell-Mediated Therapy of Spinal Cord Injury in Rat Investigators examined the efficacy of glial cell-derived neurotrophic factor (GDNF) delivered using an adenoviral vector (AdV-GDNF) and human umbilical cord blood mononuclear cells (UCB-MCs)+AdV-GDNF therapy by conducting behavioral tests on the animals and morphometric studies on the spinal cord, performing immunofluorescence analyses on glial cells, investigating the survival and migration potential of UCB-MCs, and evaluating the expression of the recombinant GDNF gene. [Spinal Cord] Abstract | Press Release |