Cord Blood Ferritin and Fibroblast Growth Factor-23 Levels in Neonates C-terminal fibroblast growth factor-23 (FGF23), but not intact FGF23 levels, are elevated in cord blood of healthy term neonates and independently associated with lower serum ferritin and higher glycemic indices. [J Clin Endocrinol Metab] Abstract | Full Article The Effect of Bisphosphonates on the Endothelial Differentiation of Mesenchymal Stem Cells Scientists evaluated the effects of various bisphosphonates on the differentiation of human placental mesenchymal stem cells along the endothelial lineage and their subsequent functional and morphogenic capabilities. [Sci Rep] Full Article Infusion of CD3/CD28 Co-Stimulated Umbilical Cord Blood T Cells at the Time of Single Umbilical Cord Blood Transplantation May Enhance Engraftment Researchers tested whether ex vivo activation by CD3/CD28 costimulation and expansion of T cells from a single umbilical cord blood graft would be safe and feasible in adults with advanced hematologic malignancies, with an overall objective of optimizing engraftment in single unit umbilical cord blood transplantation. [Am J Hematol] Abstract Endothelial Progenitor Cells Promote Efficient Ex Vivo Expansion of Cord Blood–Derived Hematopoietic Stem/Progenitor Cells Investigators designed an ex vivo culture system using endothelial progenitor cells as stroma to determine the capacity of expanding cord blood-hematopoietic stem/progenitor cells in a defined medium, the effect on engraftment of the expanded cells in a mouse model and the underlying mechanism. [Cytotherapy] Abstract The Effects of Culture Conditions on the Functionality of Efficiently Obtained Mesenchymal Stromal Cells from Human Cord Blood Scientists demonstrated 87% efficacy in generating mesenchymal stromal cells (MSCs) from cord blood. The established cells had typical MSC characteristics with reduced adipogenic differentiation potential and a unique HOX gene fingerprint. [Cytotherapy] Abstract A Chemically Defined Medium-Based Strategy to Efficiently Generate Clinically Relevant Cord Blood Mesenchymal Stromal Colonies Researchers proposed a straightforward, extremely efficient, and reliable approach to isolate and expand thoroughly characterized cord blood (CB) mesenchymal stromal cells, even when poor-quality CB units are the only disposable source or there is no space for an isolation to fail. [Cell Transplant] Abstract |