Cord Blood News Volume 8.07 | Feb 25 2016

Adapting Coculture In Vitro Models of the Blood-Brain Barrier for Use in Cancer Research: Maintaining an Appropriate Endothelial Monolayer for the Assessment of Transendothelial Migration
The authors adapted an existing in vitro model of the human blood–brain barrier for use in studying cancer cell transmigration. The model is based on the coculture of endothelial cells (derived from cord blood hematopoietic stem cells) and brain pericytes. [Lab Invest] Abstract

Hypoxic Conditioned Medium of Placenta-Derived Mesenchymal Stem Cells Protects against Scar Formation
Researchers showed that hypoxic conditioned medium of placenta-derived mesenchymal stem cells (PMSCs) reduced scar formation in vivo and inhibited the proliferation and migration of skin fibroblasts in vitro. The level of IL-10 was affected by hypoxia, treatment with IL-10 mimicked the function of hypoxic conditioned medium of PMSCs and inhibition of IL-10 reversed the protective role of hypoxic conditioned medium of PMSCs. [Life Sci] Abstract

Effect of Human Umbilical Cord Mesenchymal Stem Cell Transplantation in a Rat Model of Preeclampsia
The authors tested the effects of human umbilical cord mesenchymal stem cell transplantation on reversing preeclampsia (PE) symptoms in a lipopolysaccharide-induced rat PE model. [Reprod Sci] Abstract

Phenotypic and Functional Characterization of Mesenchymal Stem/Multipotent Stromal Cells From Decidua Parietalis of Human Term Placenta
Investigators carried out an extensive characterization of decidua parietalis of human placenta. They report that these cells express and secrete a wide range of molecules with multiple functions. [Reprod Sci] Abstract

Mesenchymal Stromal Cell-Derived Extracellular Vesicles Protect Against Acute Kidney Injury Through Anti-Oxidation by Enhancing Nrf2/ARE Activation in Rats
Extracellular vesicles (EVs) isolated from the conditioned medium of human Wharton’s Jelly mesenchymal stromal cells and human foreskin fibroblast were intravenously injected in rats immediately after 45 min of unilateral kidney ischemia. They showed that renal tubular injury was alleviated and renal function was improved by mesenchymal stem cell-EVs. [Kidney Blood Press Res] Full Article

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National Institutes of Health’s NIAID Initiating Dose Evaluation Studies in Animal Models of Pluristem’s PLX-R18 in the Treatment of Acute Radiation Syndrome
Pluristem Therapeutics Inc. announced that the National Institute of Allergy and Infectious Diseases (NIAID) will initiate studies in large animals to evaluate dosing for Pluristem’s PLX-R18 as a medical counter measure in the treatment of the hematologic components of Acute Radiation Syndrome. [Pluristem Therapeutics Inc.] Press Release

New Innovative National Center for Blood Group Genomics Created by the New York Blood Center (NYBC) in Kansas City, MO
NYBC, along with its partner organization Community Blood Center of Greater Kansas City, announced the creation of the National Center for Blood Group Genomics. Based in Kansas City, the focus of the new laboratory and research center will be national in scope, targeting the testing of blood donor and patient samples from across the nation. [New York Blood Center] Press Release

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Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

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NEW Research Technician I – Umbilical Cord Blood (Fred Hutchinson Cancer Research Center)

NEW Postdoctoral Fellow – Stem Cell Biology and Regenerative Medicine (Cleveland Clinic)

Translational Research Scientist – Hematology/Oncology (University of Chicago)

Postdoctoral Associate – Epigenetic Regulation of Normal and Leukemic Stem Cells (Sanford Burnham Prebys Medical Discovery Institute)

Postdoctoral Positions – Immunology, Cancer, and Stem Cells (University of Connecticut)

PhD Position – Stem Cells and Transplantation (University of Geneva)

Postdoctoral position – Regenerative Medicine (University of Copenhagen)

Assistant/Associate/Full Member Faculty – Myeloid Malignancies (Fred Hutchinson Cancer Research Center)

Assistant Member – Cord Blood Transplantation (Fred Hutchinson Cancer Research Center)

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