Tissue-Specific Differentiation Potency of Mesenchymal Stromal Cells from Perinatal Tissues Scientists successfully isolated and cultured mesenchymal stromal cells from amnion (AMSCs), chorion, and umbilical cord. Proliferation potential was different among them, that AMSCs revealed the lowest proliferation rate due to increased Annexin V and senescence-associated β-galactosidase positive cells. [Sci Rep] Full Article Impact of Early CMV Reactivation in Cord Blood Stem Cell Recipients in the Current Era The unique combination of higher incidence of CMV reactivation in the seropositive recipient and lower incidence of graft versus host disease in cord blood (CB) hematopoietic cell transplantation (HCT) permits a valuable design to analyze the impact of CMV reactivation. Data from 1684 patients transplanted with CB between 2003 and 2010 for AML and ALL were analyzed. [Bone Marrow Transplant] Abstract Autologous Stem Cell Transplantation for Patients Aged 60 Years or Older with Refractory or Relapsed Classical Hodgkin’s Lymphoma: A Retrospective Analysis from the French Society of Bone Marrow Transplantation and Cell Therapies (SFGM-TC) Researchers retrospectively analyzed the outcome of 91 patients aged 60 years or older with refractory/relapsed classical Hodgkin’s lymphoma who underwent autologous stem cell transplantation between 1992 and 2013 and were reported to the French Society of Bone Marrow Transplantation and Cell Therapies registry. [Bone Marrow Transplant] Abstract Cytogenetics Does Not Impact the Outcome of Adult Patients with Acute Lymphoblastic Leukemia Undergoing Allogeneic Hematopoietic Cell Transplantation Investigators retrospectively analyzed the outcome of 333 adult acute lymphoblastic leukemia patients who underwent allogeneic hematopoietic stem cell transplantation at their institution over a 10-year period. [Biol Blood Marrow Transplant] Abstract VCAM-1+ Placenta Chorionic Villi-Derived Mesenchymal Stem Cells Display Potent Pro-Angiogenic Activity Researchers assessed whether VCAM-1 can be used as a marker of mesenchymal stem cells subpopulation with superior angiogenic potential. [Stem Cell Res Ther] Full Article DMSO- and Serum-Free Cryopreservation of Wharton’s Jelly Tissue Isolated from Human Umbilical Cord Investigators compared the effect of two different cryoprotectants (dimethyl sulfoxide [DMSO] & cocktail solution) on post-thaw cell behavior upon freezing of Wharton’s jelly tissue following two different freezing protocols. [J Cell Biochem] Abstract A Novel Molecular and Functional Stemness Signature Assessing Human Cord Blood-Derived Endothelial Progenitor Cell Immaturity To better characterize cord blood-derived-endothelial colony forming cells stemness, scientists quantified their clonogenic potential and demonstrated that they were reprogrammed into induced pluripotent stem cells more efficiently and rapidly than adult endothelial cells. [PLoS One] Full Article |