Cord Blood News 8.24 June 23, 2016 | |
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TOP STORYThe authors showed that human umbilical cord-derived mesenchymal stem cells infected by Ad-hTERTp-IL24 followed by LentiR.E1A infection could specifically migrate to HepG2 tumor cells and support adenoviral replication in vitro and in vivo 36 hours after LentiR.E1A infection [Oncotarget] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Preterm White Matter Brain Injury Is Prevented by Early Administration of Umbilical Cord Blood Cells Researchers assessed the neuroprotective effects of umbilical cord blood cells and optimal administration timing in a fetal sheep model of preterm brain injury. [Exp Neurol] Abstract Amnion-Epithelial-Cell-Derived Exosomes Demonstrate Physiologic State of Cell under Oxidative Stress Investigators determined amnion epithelial cells (AECs) exosome characteristics and their cargo reflected the physiologic status of the cell of origin and suggests that AEC-derived exosomal p38 MAPK plays a major role in determining the fate of pregnancy. [PLoS One] Full Article Reconstitution of Immune Cell in Liver and Lymph Node of Adult- and Newborn-Engrafted Humanized Mice The authors compared reconstitution levels in a variety of immunological tissues, including the lymph node and liver, between mice engrafted intravenously as adults and intrahepatically in newborns. CD34+ cells were enriched from cord blood and transplanted intravenously into irradiated adult NOD-Rag1-/-IL2rγ-/- (NRG) mice or intra-hepatically into irradiated newborn NRG mice. [BMC Immunol] Full Article Allogeneic multiplacenta derived hematopoietic and mesenchymal stem cells/cytokines were intraperitoneally injected into a moderate dose of total body irradiation-induced mouse bone marrow damage model a single time. Each mouse that received placenta-derived stem cells exhibited positive donor hematopoietic and mesenchymal stem cell engraftment both in the bone marrow and peripheral blood after transplantation. [Cytotechnology] Abstract The authors investigated the retinal pigment epithelium differentiation from umbilical cord blood-derived mesenchymal stem cells via treating anti-miR-410. [J Vet Sci] Abstract | |
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REVIEWSTreating Hemoglobinopathies Using Gene-Correction Approaches: Promises and Challenges The authors describe the development and potential application of gene therapy and precision genome-editing approaches for treating sickle cell disease and β-thalassemia. The opportunities and challenges in advancing a curative therapy for hemoglobinopathies are also discussed. [Hum Genet] Abstract Visit our reviews page to see a complete list of reviews in the cord blood research field.
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INDUSTRY NEWSCellectis announced that the first patient has been treated in the Phase I study of UCART19 in pediatric acute B-ALL at the University College of London. [Cellectis] Press Release ARIAD Pharmaceuticals, Inc. announced the initiation of a New Drug Application submission for its investigational anaplastic lymphoma kinase inhibitor, brigatinib, to the U.S. Food and Drug Administration. [ARIAD Pharmaceuticals, Inc.] Press Release | |
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EVENTSNEW 3rd Congress on Controversies in Thrombosis and Hemostasis (CiTH) Visit our events page to see a complete list of events in the cord blood community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow – Characterizing and Targeting Cancer Stem Cells (City of Hope) Technical Sales Representative (STEMCELL Technologies Inc.) Postdoctoral Fellow – Tumor Microenvironment and Cancer Stem Cells (Duke University) Postdoctoral Research Position – Pediatric Hematology and Oncology (Hannover Medical School) Research Assistants and Associates – Leukemia and Stem Cell Biology (King’s College London) Postdoctoral Research Associate – Myeloid Leukemia (Upstate Medical University) Postdoctoral Research Associate – TAM-Family Kinases in Leukemogenesis (Emory University) Postdoctoral Fellow – Hematology/Oncology (Boston Children’s Hospital) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Cord Blood News Volume 8.24 | Jun 23 2016