Cord Blood News 8.46 November 24, 2016 | |
| |
TOP STORYDNA Methylation Dynamics of Human Hematopoietic Stem Cell Differentiation Investigators used a meta-epigenomic approach that combines DNA methylation profiles across many small pools of cells and performed single-cell methylome sequencing to assess cell-to-cell heterogeneity. The resulting dataset identified characteristic differences between hematopoietic stem cells derived from fetal liver, cord blood, bone marrow, and peripheral blood. [Cell Stem Cell] Full Article | Graphical Abstract | |
| |
PUBLICATIONS(Ranked by impact factor of the journal)Scientists compared mesenchymal stem/stromal cells from human umbilical cord, grown in xeno-free conditions, with mesenchymal stem/stromal cells from human bone marrow, in a rat model of E. coli pneumonia. In addition, they determined the potential for umbilical cord-mesenchymal stem/stromal cells to reduce E. coli-induced oxidant injury. [Crit Care Med] Abstract Researchers investigated the mechanism by which netrin-1 (Ntn-1) promotes the proliferation of hUCB-MSCs with regard to the regeneration of injured tissues. They found that Ntn-1 induces the proliferation of hUCB-MSCs mainly via Inα6β4 coupled with c-Src. [Sci Rep] Full Article The authors examined the effects of light-emitting diode photobiomodulation therapy on the proliferation and differentiation of human umbilical cord mesenchymal stem cells cultured in osteogenic differentiation medium. [Sci Rep] Full Article With the use of a Japanese transplant registry database, the authors analyzed 3933 adult recipients who underwent hematopoietic cell transplantation between 2006 and 2013 from an 8/8 HLA-matched unrelated bone marrow donor, an HLA-mismatched unrelated bone marrow donor, or unrelated cord blood. [Am J Hematol] Abstract Investigators found that sodium nitroprusside treatment of lineage negative (Lin–) cells leads to an increase in the numbers of Lin−Sca-1+c-Kit+CD34− cells in them. Preliminary experiments performed on cord blood-derived and mobilized peripheral blood-derived cells revealed that nitric oxide exerts age-dependent contrasting effects on human hematopoietic stem cells as well. [Stem Cell Res Ther] Full Article Investigators present a defined 3D differentiation protocol of Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs) into definitive endoderm cells. WJ-MSCs were cultured in suspension to generate spheroids, about 1500 cells each, for seven days. [Stem Cell Res Ther] Full Article Researchers investigated the osteogenic potential of three different mesenchymal stem cells derived from human bone marrow, umbilical cord Wharton’s jelly, and adipose seeded on a recently developed nanocomposite scaffold (bioactive glass/gelatin) implanted in rat animal models with critical size calvarial defects. [J Biomed Mater Res B Appl Biomater] Abstract | |
| |
REVIEWSThe authors review the rationale for using mesenchymal stromal cells (MSCs), particularly Wharton’s jelly-MSCs, as a feeder layer for umbilical cord blood-HSPCs ex vivo expansion. In addition, they report the main findings attesting the use of these MSCs as a support in hematopoiesis. [Stem Cell Rev] Abstract Mesenchymal Stem Cells-Derived Exosomal MicroRNAs Contribute to Wound Inflammation The authors describe a signature of three specific microRNAs (miRNAs) present in human umbilical cord mesenchymal stem cell-derived exosomes identified microarray chip analysis and focus on the inflammatory regulatory functions of these immune-related miRNAs. [Sci China Life Sci] Full Article Visit our reviews page to see a complete list of reviews in the cord blood research field. | |
| |
INDUSTRY NEWS$25 Million Awarded to Center for Study of Regulatory Science The FDA is funding a collaboration between Stanford and UCSF to improve the regulatory infrastructure that helps to shape modern biomedical research. [Stanford Medicine] Press Release Center for Regenerative Medicine Receives Three Prestigious NIH Awards To Further Stem Cell Research The Center for Regenerative Medicine at Boston Medical Center and Boston University School of Medicine has received three prestigious awards from the National Institutes of Health (NIH) to further its commitment to induced pluripotent stem cell research and education. [Boston University School of Medicine] Press Release | |
| |
POLICY NEWSNgAgo Gene-Editing Controversy Escalates in Peer-Reviewed Papers A heated dispute over gene-editing that began online is now playing out in the scientific literature. Six months ago, Chinese researchers reported that an enzyme called NgAgo could be used to edit mammalian genes – and that it might be more accurate and more versatile than the popular CRISPR-Cas9 gene-editing technique. [Nature News] Editorial Immigrant and Minority Scientists Shaken by Trump Win Scientists are reconsidering whether to work or study in the United States. Worries include job prospects, discrimination—and safety. [Nature News] Editorial Peer-Review ‘Heroes’ Do Lion’s Share of the Work In 2015, the number of scientists in the life sciences far exceeded the demand on them for peer review, according to Michail Kovanis, a computational physicist at the French National Institute of Health and Medical Research in Paris, and his colleagues. Yet their study also suggests – based on data obtained from a rapidly-growing website of peer-review activity – that 20% of the scientists undertook between 69% and 94% of reviews last year, lending credence to some researchers’ complaints that they are overburdened. [Nature News] Editorial Cautious Welcome for UK’s Vague £2 Billion Research Pledge UK scientists have welcomed a surprise government promise to invest an extra £2 billion (US$2.5 billion) per year into research and development by 2020 – although details of the pledge will not be made clear for at least another two days. [Nature News] Editorial
| |
EVENTSNEW ISSCR Annual Meeting 2017 Visit our events page to see a complete list of events in the community.
| |
JOB OPPORTUNITIESPostdoctoral Position – Leukemia Research (University Medicine Mannheim) Postdoctoral Position – Stem Cell Biology and Hematology (University of São Paulo) Postdoctoral Position – Immunobiology of Stromal Cells (Institut Pasteur) MRC WIMM Prize PhD Studentships (University of Oxford) Research Associate – Hematology (Editas Medicine) Assistant Member Faculty – PlatinumImmunotherapy (Fred Hutchinson Cancer Research Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Cord Blood News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|