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Pulmonary Cell News| Cord Blood News 9.21 June 1, 2017 | |
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TOP STORYScientists showed that CDC42 acts as an essential factor in regulating cell proliferation and also takes part in lipotoxic effects of palmitate in human umbilical cord Wharton’s jelly derived mesenchymal stromal cells (WJ-MSCs). Cultured human bone marrow-MSCs, adipose tissue-MSCs, and umbilical cord WJ-MSCs derived cells had varying pro-inflammatory cytokine secretion levels and cell death rates when treated by palmitate. [Stem Cells Dev] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Investigators showed that hemogenic niches can be engineered using microfabrication strategies by micropatterning human pluripotent stem cell-derived hemogenic endothelial cells into spatially-organized, size-controlled colonies. Intra-colony analysis revealed radial organization of CD34 and VECAD expression levels, with CD45+ blood cells emerging primarily from the colony centroid area. [Nat Commun] Full Article Hematopoietic stem cells (HSCs) efficiently self-renew in niches where they interact with three-dimensional (3D) extracellular matrix and stromal cells. Co-cultures of CD34+ cells and mesenchyme stem cells derived from human amniotic membrane (hAMSCs) on the basis of biomimetic macroporous 3D poly(ε-caprolactone) (PCL) scaffolds were developed, and scaffolds and hAMSCs were applied to mimic structural and cellular microenvironment of HSCs. The influence of scaffolds, feeder cells, and contact manners on expansion and stemness maintenance of CD34+ cells was investigated. [Macromol Biosci] Abstract Investigators generated ten human amniotic mesenchymal stromal cell (hAMSC) lines under human umbilical cord blood (hUCS) serum-supplemented medium (xeno-free culture) and fetal bovine serum-supplemented medium and investigated carcinogenicity and immunosuppressive properties in the resultant hAMSC lines. Xeno-free hAMSC lines retained essential stem cell characteristics, with a high degree of certainty for meeting biosafety and carcinogenicity standards for a xeno-free system supplemented with allogenic hUCS. [Cytotherapy] Abstract The authors evaluated the effect of mesenchymal stem cells (MSCs) in the functional and the structural improvement of doxorubicin (DOX)-induced cardiomyopathy in rats. DOX-administered rats showed significant functional and structural deterioration. Human umbilical cord blood-MSCs significantly ameliorated the cardiotoxic manifestations as shown by biochemical, functional and structural cardiac improvement. [J Cell Biochem] Abstract Although human term placenta-derived primary cytotrophoblasts (pCTBs) represent a good human syncytiotrophoblast model, in vitro culture of pCTBs is not always easily accomplished. Scientists examined Y-27632’s potential for enhancing pCTB adhesion, viability and differentiation. [PLoS One] Full Article Researchers compared the immunogenicity of endothelial progenitor cells (EPCs), adipose tissue (AD)-derived mesenchymal stem cells (MSCs) and umbilical cord (UC)-derived MSCs by flow cytometry and the mixed lymphocyte reaction. UC-MSCs expressed lower levels of IFN-γ receptor mRNA when compared with EPCs and AD-MSCs. EPCs stimulated higher rates of proliferation of lymphocytes than AD-MSCs and UC-MSCs. [PLoS One] Full Article External Magnetic Field Promotes Homing of Magnetized Stem Cells Following Subcutaneous Injection The authors studied the ability of superparamagnetic iron oxide nanoparticles-labeled Wharton’s jelly of the human umbilical cord-derived mesenchymal stem cells to carry the green fluorescent protein (GFP) gene to cutaneous injury sites in a murine model. The results showed that GFP could be intensively detected around the wound in vivo 24 hours after the cells were injected. [BMC Cell Biol] Full Article Investigators characterized leukocyte reconstitution in NSG mice, which were sublethally irradiated and transplanted with human cord blood-derived CD34+ cells at newborn age, longitudinally in peripheral blood and, for more detailed analyses, cross-sectionally in peripheral blood, spleen and bone marrow at different time points. [BMC Immunol] Full Article | |
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REVIEWSThe authors wish to increase the awareness of oncology practitioners to the availability of alternative donor stem cell transplants for patients with hematologic malignancies. Despite new agents, stem cell transplant remains the only curative therapy for many patients with acute and chronic leukemia, myelodysplasia, and lymphoma. Given the variety of different donor stem cell sources available, nearly every patient who needs an allogeneic stem cell transplant will have a donor. [Oncologist] Abstract Visit our reviews page to see a complete list of reviews in the cord blood research field. | |
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INDUSTRY NEWSStemCyte, Inc. announced a renewed strategic partnership with the Neonatal Research Institute at Sharp Mary Birch Hospital for Women & Newborns. The strategic partnership designed to enhance resources for collection, processing and banking of this vital potentially life-saving resource of cord blood stem cells as well as their availability for new research. [StemCyte, Inc. (PR Newswire Association LLC.)] Press Release The University of Kansas Cancer Center has announced that it will join a consortium with the Dana-Farber Cancer Institute, in collaboration with The Leukemia & Lymphoma Society, to bring clinical trials testing innovative blood cancer therapies to Kansas City. [University of Kansas Cancer Center] Press Release | |
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POLICY NEWSWeb of Science Owner Buys up Booming Peer-Review Platform The owner of the vast science-citation database Web of Science — Clarivate Analytics — is buying up a firm that has gathered hundreds of thousands of peer-review records, in a deal that could lead to new ways of organizing scientific peer review and preventing peer-review fraud. [Nature News] Editorial Pay-to-View Blacklist of Predatory Journals Set to Launch The blacklist is dead; long live the blacklist. Five months after a widely read blog listing possible ‘predatory’ scholarly journals and publishers was shut down, another index of untrustworthy titles is appearing — although this version will be available only to paying subscribers. [Nature News] Editorial NIH Finds Using Anonymous Proposals to Test for Bias Is Harder than It Looks An effort to test whether reviewers are biased against blacks applying for grants from the National Institutes of Health (NIH) is proving to be much harder to carry out than expected. [ScienceInsider] Editorial
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EVENTSNEW Standardization of the Hematopoietic Progenitor Assay Training Course Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow – Hematopoietic Stem Cells (University of Pennsylvania) Postdoctoral Research Fellow – Sleeping Beauty (Moffitt Cancer Center) Postdoctoral Research Position – Lymphoma (Memorial Sloan Kettering Cancer Center) Postdoctoral Fellow – Molecular Hematology (University of Gothenburg, Institute of Biomedicine) Postdoctoral Position – Acute Myeloid Leukemia (LMU Munich) Postdoctoral Position – Mesenchymal Stem Cell (Longboats Explorers Inc.) Full Member Faculty – Hematopoietic Cell Transplant Program (Fred Hutchinson Cancer Research Center) Assistant Member Faculty – Platinum/Immunotherapy (Fred Hutchinson Cancer Research Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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