Cord Blood News Volume 9.41 | Oct 19 2017

TOP STORY

Human Mesenchymal Stromal Cells Transplanted into Mice Stimulate Renal Tubular Cells and Enhance Mitochondrial Function

Scientists showed that human umbilical cord-MSCs transplanted into mice stimulate tubular cells to regain mitochondrial mass and function, associated with enhanced microtubule-rich projections that appear to mediate mitochondrial trafficking to create a reparative dialogue among adjacent tubular cells. [Nat Commun] Full Article

(Ranked by impact factor of the journal)

Therapeutic Potential of hAECs for Early Achilles Tendon Defect Repair through Regeneration

The authors investigated the efficacy of transplanted human amniotic epithelial cells (hAECs) by testing their early regenerative properties and mechanisms involved on a validated ovine Achilles tendon partial defect performed on 29 animals. The injured tendons treated with hAECs recovered rapidly, in 28 days, structural and biomechanical properties undertaking a programmed tissue regeneration, differently from the spontaneous healing tissues. [J Tissue Eng Regen Med] Abstract

Treatment Evaluation of Wharton’s Jelly-Derived Mesenchymal Stem Cells Using a Chronic Salpingitis Model: An Animal Experiment

Researchers evaluated new methods to repair the reproductive function of the oviduct, thereby allowing gametes to combine and grow in vivo under natural circumstances. Oviducts of New Zealand rabbits in the untreated control group showed structural failure and abnormal supermicrostructure of epithelial cells. Wharton’s jelly-derived MSCs could partially repair the structure and supermicrostructure of the tubal epithelium. [Stem Cell Res Ther] Full Article

Human Umbilical Cord Wharton Jelly Cells Promote Extra-Pancreatic Insulin Formation and Repair of Renal Damage in STZ-Induced Diabetic Mice

Investigators evaluated the therapeutic effect and fate of high doses of human umbilical cord Wharton jelly cells (hUCWJCs) after IP administration to streptozotocin (STZ)-induced diabetic mice. hUCWJCs migrated to the STZ-damaged organs and contributed to lower blood glucose levels in 30% of the treated mice. [Cell Commun Signal] Full Article

Hyperbaric Oxygen Treatment Effects on In Vitro Cultured Umbilical Cord Blood CD34⁺ Cells

Researchers examined how direct treatment of umbilical cord blood (UCB)-CD34⁺ cells with hyperbaric oxygen (HBO) influences their differentiation, proliferation and in vitro transmigration. Their results showed that HBO treatment diminishes proliferation and in vitro transmigration of UCB-CD34⁺ cells. [Cytotherapy] Abstract

Cord Blood–Derived T Cells Allow the Generation of a More Naïve Tumor-Reactive Cytotoxic T-Cell Phenotype

Scientists describe functional differences between cord blood (CB) and peripheral blood (PB) T cells stimulated with different cytokine combinations involved in central T-cell activation. After antigen-independent stimulation, activated CD8⁺ CB T cells exhibited stronger proliferation and function than those from PB. [Transfusion] Abstract

Transgenic Expression of Human Cytokines in Immunodeficient Mice Does Not Facilitate Myeloid Expansion of BCR–ABL1 Transduced Human Cord Blood Cells

Researchers used non-obese diabetic/severe combined immunodeficient IL2-receptor gamma deficient mice expressing human SCF, IL–3 and GM–CSF, that should have been superior in supporting human, and particularly, myeloid cell engraftment, to expand BCR–ABL1 expressing human cells in order to model chronic myeloid leukemia. [PLoS One] Full Article

The Effects of Liquid Crystal-Based Composite Substrates on Cell Functional Responses of Human Umbilical Cord-Derived Mesenchymal Stem Cells by Mechano-Regulatory Process

Investigators developed a novel type of liquid crystal-based matrix by combining the elastic property of polyurethane with viscoelastic liquid crystal to generate a soft elastic response resembling physical microenvironment of stem cell niche, and explored the mechano-driving cell behaviors. [J Biomater Appl] Abstract

Short Review on Human Umbilical Cord Lining Epithelial Cells and Their Potential Clinical Applications

The authors discuss some of the advantages afforded by cord lining epithelial cells over other stem cell lines and then delineate their potential use in various clinical applications. [Stem Cell Res Ther] Full Article

Transamniotic Stem Cell Therapy: A Novel Strategy for the Prenatal Management of Congenital Anomalies

Transamniotic stem cell therapy is an emerging therapeutic concept for the management of congenital anomalies based on the augmentation of the biological role of select populations of stem cells that already occur in the amniotic fluid for targeted therapeutic benefit. [Pediatr Res] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

Bio-Tissue Announces Strategic Agreement with Optima Pharmazeutische GmbH to Distribute Its Natural Ocular Cleanser in Germany

Bio-Tissue, Inc. announced a strategic agreement with Optima Pharmazeutische GmbH, a leading distributor of ophthalmic products for the treatment of dry eye, blepharitis and meibomian gland dysfunction in Germany and Austria. The agreement supports efforts to bring Bio-Tissue’s natural ocular cleanser formulated with 4-Terpineol, Cliradex^®, to the German eye care professionals market. [Bio-Tissue, Inc. (Business Wire, Inc.)] Press Release

Strategic Partner Secured to Expand into the Middle East, N. Africa and Asia

WideCells Group PLC announced that it has signed an exclusive Heads of Terms agreement with multi-sector advisory business White Apex General Trading to sell and promote the group’s stem cell services in the Middle East and North Africa and Asia-Pacific territories. [WideCells Group PLC] Press Release

Rand Paul Takes a Poke at U.S. Peer Review Panels

Senate Republicans have launched a new attack on peer review by proposing changes to how the U.S. government funds basic research. [ScienceInsider] Editorial

Top Chinese University to Consider Social-Media Posts in Researcher Evaluations

One of China’s most prestigious universities plans to give some articles in newspapers and posts on major social-media outlets the same weight as peer-reviewed publications when it evaluates researchers. [Nature News] Editorial

Japanese Research Leaders Warn about National Science Decline

As Japan heads towards a national election, scientific leaders worry that the outcome will do little to address long-standing concerns about the country’s deteriorating research landscape. They say that a decline in funding and a shift away from basic research has undermined Japan’s capacity to compete against both established scientific powerhouses and emerging ones such as China. [Nature News] Editorial

German Researchers Resign from Elsevier Journals in Push for Nationwide Open Access

Five leading German scientists have resigned from their editorial positions at journals published by Elsevier, the latest step in a battle over open-access and subscription policies between the Dutch publishing giant and a consortium of German libraries, universities, and research institutes. [ScienceInsider] Editorial

NEW 25^th Biennial Congress of the European Association for Cancer Research (EACR)
June 30-July 3, 2018
Amsterdam, Netherlands

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Opportunities – Hematological Malignancies (Albert Einstein College of Medicine)

Scientists – In Vivo Leukemia Modeling (University of Copenhagen)

Faculty Positions – Hematological Malignancies (University of Alabama at Birmingham)

Postdoctoral Fellow – Hematology (University of Tennessee Health Science Center)

Postdoctoral Research Fellow – Hematopoietic Stem Cell Development (Cincinnati Children’s Hospital Medical Center)

Postdoctoral Position – Mesenchymal Stem Cells (University of Southern California)

Postdoctoral Fellowship – Development & Epigenetics (Centre National de la Recherche Scientifique)

Postdoctoral Fellow – Hematopoietic Stem Cells (Memorial Sloan Kettering Cancer Center)

Postdoctoral Fellowship – Functional Genomics of Human Hematopoiesis (Boston Children’s Hospital and Harvard Medical School)

Technical Director – Personalized Stem Cell Banking (Brilliant Research)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Cord Blood News? Click here to submit!

Comments or suggestions? Submit your feedback here.