Dermal Cell News Volume 1.00 | May 4 2015

Anti-PDGF Receptor β Antibody-Conjugated Squarticles Loaded with Minoxidil for Alopecia Treatment by Targeting Hair Follicles and Dermal Papilla Cells
Investigators developed lipid nanocarriers, called squarticles, conjugated with anti-platelet-derived growth factor-receptor β antibody to determine whether targeted Minoxidil delivery to the follicles and dermal papilla cells could be achieved. [Nanomedicine] Abstract

Activation and Regulation of the Granulation Tissue Derived Cells with Stemness-Related Properties
Granulation tissue derived cells (GTCs) were isolated and their in vitro proliferation, self-renewing, migration, and multi-differentiation capabilities were assessed. Combined radiation and a skin wound model were used to investigate the therapeutic effects of GTCs. [Stem Cell Res Ther] Full Article

Ultraviolet B (UVB) Inhibits Skin Wound Healing by Affecting Focal Adhesion Dynamics
Researchers demonstrated that UVB can delay the wound healing progress in vivo with a murine model of full thickness skin wound. [Photochem Photobiol] Abstract

Adipose-Derived Stromal Cell Cluster with Light Therapy Enhance Angiogenesis and Skin Wound Healing in Mice
The aim of this study was to investigate the effects of low-level light therapy (LLLT) on transplanted cluster human adipose-derived mesenchymal stem cells (hASCs) in a skin wound animal model. The hASCs were cultured in monolayer or clusters. The LLLT, hASCs, hASC clusters, and hASC clusters transplantation with LLLT were applied to the wound bed in athymic mice. [Biochem Biophys Res Commun] Abstract

SKIN CANCERS & DISORDERS

Protein Tyrosine Kinase 6 Regulates UVB Induced Signaling and Tumorigenesis in Mouse Skin
The authors found that Protein Tyrosine Kinase 6 (PTK6) expression increases in the epidermis following UVB treatment. To evaluate the roles of PTK6 in the skin following UVB-induced damage, they exposed back skin of Ptk6^+/+ and Ptk6^-/- SENCAR mice to incremental doses of UVB for thirty weeks. [J Invest Dermatol] Abstract

Rho Kinase Inhibitor Fasudil Suppresses Vasculogenic Mimicry of B16 Mouse Melanoma Cells Both In Vitro and In Vivo
Scientists established an in vitro model of vasculogenic mimicry (VM) using 3-dimensional cell culturing of mouse B16 melanoma cells and studied VM in vivo by transplanting B16 mouse melanoma cells into C57/BL mice. [Mol Cancer Ther] Abstract

Evaluation of ⁶⁸Ga- and ¹⁷⁷Lu-DOTA-PEG₄-LLP2A for VLA-4 Targeted PET Imaging and Treatment of Metastatic Melanoma
Researchers evaluated ¹⁷⁷Lu- and ⁶⁸Ga-labeled DOTA-PEG4-LLP2A as a very late antigen-4 (VLA-4) targeted radiotherapeutic with a companion PET agent for diagnosis and monitoring metastatic melanoma treatment. DOTA-PEG₄-LLP2A was synthesized by solid phase synthesis. The affinity of ¹⁷⁷Lu- and 68Ga-labeled DOTA-PEG₄-LLP2A to VLA-4 was determined in B16F10 melanoma cells by saturation binding and competitive binding assays, respectively. [Mol Pharm] Abstract

Chemokine-Like Factor 1-Derived C-Terminal Peptides Induce the Proliferation of Dermal Microvascular Endothelial Cells in Psoriasis
To explore its role in the pathogenesis of psoriasis, the expression of both chemokine-like factor 1 (CKLF1) and its receptor (CCR4) was determined in psoriatic lesions. Also, the effect of the C-terminal peptides (C19 and C27) of CKLF1 on the proliferation of human umbilical vein endothelial cells was studied in vitro. [PLoS One] Full Article

Tissue Engineering Strategies as Tools for Personalized Meningioma Treatment
Researchers constructed cancer-like tissues to be used as tools for determining the most effective drug for an individual patient. Using tissue engineering strategies, they generated two different solid tumor-like tissues in vitro, a neuronal tumor (meningioma) and a nonmelanoma skin cancer. [Artif Organs] Abstract

Somatic Stem Cell Heterogeneity: Diversity in the Blood, Skin and Intestinal Stem Cell Compartments
Under stress conditions such as acute injury, the surprising developmental flexibility of blood, skin and intestinal epithelium stem cells enables them to adapt to diverse roles and to acquire different regeneration capabilities. This paradigm shift raises many new questions about the developmental origins, inter-relationships and molecular regulation of these multiple stem cell types. [Nat Rev Mol Cell Biol] Abstract

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Cytori Reports Preclinical and Mechanistic Data Supporting Use of Cytori Cell Therapy in Wounds Combining Thermal Burn and Radiation Exposure
Cytori Therapeutics, Inc. presented data from two preclinical studies funded through its contract with the United States Biomedical Advanced Research and Development Authority (BARDA) at the 2015 American Burn Association Meeting this week in Chicago. [Press release from Cytori Therapeutics, Inc. discussing research presented at the 2015 American Burn Association Meeting, Chicago] Press Release

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Bristol-Myers Squibb Receives Positive CHMP Opinion in the European Union for Opdivo (nivolumab) for the Treatment of Advanced Melanoma in Both First-Line and Previously Treated Patients
Bristol-Myers Squibb Company announced that the Committee for Medicinal Products for Human Use of the European Medicines Agency has recommended that Opdivo (nivolumab), a PD-1 immune checkpoint inhibitor, be granted approval for use in both first-line and previously treated patients with advanced (unresectable or metastatic) melanoma. [Bristol-Myers Squibb] Press Release

SolaranRx’s SRX-1177 Receives FDA Orphan Drug Designation as Malignant Melanoma Treatment
SolaranRx announced that the U.S. Food and Drug Administration (FDA) has granted Orphan Drug Designation to the company’s lead product, SRX-1177, for the treatment of stage IIB to IV malignant melanoma, a deadly form of skin cancer. [SolaranRx] Press Release

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

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NEW Postdoctoral Fellow – Epidermal Growth, Inflammation and Carcinogenesis (Duke University School of Medicine)

NEW Chair of the Department of Dermatology (University of California, Davis)

NEW Faculty Positions – Stem Cell & Regenerative Medicine (University of Texas Medical School at Houston)

NEW Dermatology Specialty Representative (Celgene Corporation)

NEW Postdoctoral Positions – Molecular Cancer Biology (University of Pennsylvania)

NEW PhD Position – Decoding Gene Regulation in Cancer (University of Leuven)

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