DERMAL STEM CELLS & TISSUE REGENERATION Rapidly Light-Activated Surgical Protein Glue Inspired by Mussel Adhesion and Insect Structural Crosslinking Researchers report a new light-activated, mussel protein-based bioadhesive (LAMBA) inspired by mussel adhesion and insect dityrosine crosslinking chemistry. LAMBA exhibited substantially stronger bulk wet tissue adhesion than commercially available fibrin glue and good biocompatibility in both in vitro and in vivo studies. [Biomaterials] Full Article cAMP Promotes Cell Migration through Cell Junctional Complex Dynamics and Actin Cytoskeleton Remodeling: Implications in Skin Wound Healing 8-Bromo cAMP-treated mESCs showed significant wound closure and improved neovascularization. Moreover, 8-Bromo cAMP stimulated mESCs migration into the wound bed. [Stem Cells Dev] Abstract Expression Profiles of Neuropeptides, Neurotransmitters, and Their Receptors in Human Keratocytes In Vitro and In Situ Researchers assessed the endogenous intracellular and secreted levels of the neuropeptides substance P and neurokinin A, and of the neurotransmitters acetylcholine, catecholamines (adrenaline, noradrenaline and dopamine), and glutamate, as well as the expression profiles of their receptors, in human primary keratocytes in vitro and in keratocytes of human corneal tissue sections in situ. [PLoS One] Full Article SKIN CANCERS & DISORDERS CCN1, a Pro-Inflammatory Factor, Aggravates Psoriasis Skin Lesions by Promoting Keratinocyte Activation The authors demonstrated that CCN1, an extracellular matrix protein that is also considered a pro-inflammatory factor, is highly expressed in the lesional skin of psoriasis patients, as well as in that of imiquimod- and IL-23-treated psoriasis-like mice. [J Invest Dermatol] Abstract Invasion of Herpes Simplex Virus Type 1 into Murine Epidermis: An Ex Vivo Infection Study Investigators report how tissue has to be prepared to be susceptible to herpes simplex virus type 1 infection. Most efficient infection of the epidermis was achieved by removing the dermis. [J Invest Dermatol] Abstract PAX3 and FOXD3 Promote CXCR4 Expression in Melanoma Researchers found melanoma cells expressed two CXCR4 isoforms, the common version and a variant that is normally restricted to cells during development or to mature blood cells. [J Biol Chem] Abstract | Full Article Unique MicroRNAs Appear at Different Times during the Course of a Delayed-Type Hypersensitivity Reaction in Human Skin Scientists generated global microRNA expression profiles (using next-generation sequencing) of diphencyprone reactions in skin of seven healthy volunteers at three, 14, and 120 days after challenge. [Exp Dermatol] Abstract VS-5584, a Novel PI3K-mTOR Dual Inhibitor, Inhibits Melanoma Cell Growth In Vitro and In Vivo The authors evaluated the potential anti-melanoma effect of VS-5584, a novel and highly potent Phosphatidylinositol 3-kinase (PI3K)-AKT-mammalian target of rapamycin (mTOR) dual inhibitor. They demonstrated that VS-5584 potently inhibited survival and proliferation of established and primary human melanoma cells, but was non-cytotoxic to non-cancerous human skin keratinocytes and B10BR murine melanocytes. [PLoS One] Full Article |