Dermal Cell News Volume 1.17 | Sep 21 2015

Astragulus Polysaccharide-Loaded Fibrous Mats Promote the Restoration of Microcirculation in/around Skin Wounds to Accelerate Wound Healing in a Diabetic Rat Model
A bioactive natural substance of Astragalus polysaccharide (APS) was embedded into fibrous tissue engineering scaffolds (TES) by electrospinning. The administration of APS-loaded TES on the skin wound in a diabetic rat model led to a dose-dependent promotion in skin blood flow around wounds and an increase in endoglin expression and microvessel density in regenerated skin tissues. [Colloids Surf B Biointerfaces] Abstract

Myofibroblasts Contribute to but Are Not Necessary for Wound Contraction
Scientists utilized alpha-smooth muscle actin null mice to determine what role fibroblasts play in wound contraction. [Lab Invest] Abstract

Golgi Associated HIF1a Serves as a Reserve in Melanoma Cells
Investigators showed that hypoxia-inducible factor-1 alpha (HIF1a) protein degradation is resistant to lysosomal inhibition and that HIF1a is associated with the Golgi compartment in melanoma cells. [J Cell Biochem] Abstract

Upregulation of miR-203 and miR-210 Affect Growth and Differentiation of Keratinocytes after Exposure to Sulfur Mustard in Normoxia and Hypoxia
The authors provided evidence that miR-203 and miR-210 are key regulators in normal and sulfur mustard-impaired keratinocyte functionality. [Toxicol Lett] Abstract

SKIN CANCERS & DISORDERS

NFATc2 Is an Intrinsic Regulator of Melanoma Dedifferentiation
Scientists identified NFATc2 transcription factor as an intrinsic regulator of human melanoma dedifferentiation. They found that NFATc2 controls melanoma dedifferentiation by inducing expression in neoplastic cells of membrane-bound tumor necrosis factor-α (mTNF-α) and that melanoma-expressed TNF-α regulates a c-myc-Brn2 axis. [Oncogene] Abstract

EBI3 Downregulation Contributes to Type I Collagen Overexpression in Scleroderma Skin
Scientists found that collagen mRNA stability was reduced by EBI3 via the induction of miR-4500. The IL-35 levels in the sera or on the surface of T cells were not altered in systemic sclerosis (SSc) patients, while EBI3 expression was decreased in the keratinocytes of the epidermis and regulatory T cells of the dermis in SSc skin compared with normal skin, which may induce collagen synthesis in SSc dermal fibroblasts. [J Immunol] Abstract

NOD2 and TLR2 Ligands Trigger the Activation of Basophils and Eosinophils by Interacting with Dermal Fibroblasts in Atopic Dermatitis-Like Skin Inflammation
Scientists used a typical mouse model of atopic dermatitis-like skin inflammation and found that Staphylococcus aureus-associated nucleotide-binding oligomerization domain-containing protein 2 (NOD2) and toll-like receptor 2 (TLR2) ligands exacerbated atopic dermatitis-like symptoms, which were further deteriorated by the in vivo expansion of basophils and eosinophils. [Mol Immunol] Abstract

Red Light Combined with Blue Light Irradiation Regulates Proliferation and Apoptosis in Skin Keratinocytes in Combination with Low Concentrations of Curcumin
Scientists showed that curcumin at low concentrations has a strong anti-proliferative effect on TNF-α-induced psoriasis-like inflammation when applied in combination with light-emitting-diode devices. [PLoS One] Full Article

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Nektar Presents Data Demonstrating that NKTR-214, a CD122-Biased Immunostimulatory Cytokine, Induces Durable and Specific Anti-Tumor Immunity As a Single-Agent and When Combined with Checkpoint Inhibitors in Preclinical Models
Nektar Therapeutics announced positive preclinical results for NKTR-214, a CD122-biased cytokine designed to preferentially stimulate the production and maintenance of tumor-killing T cells which are found naturally in the body. [Nektar Therapeutics] Press Release

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NEW Senior Stem Cell Scientist (Medicines and Healthcare products Regulatory Agency)

Professor – Dermatology and Venerology (University of Munster)

Postdoctoral Fellow – Cancer Genetics (Feinberg School of Medicine)

Postdoctoral Fellow – HMGA Chromatin Remodeling Proteins in Cancer and Stem Cell Biology (Johns Hopkins University School of Medicine)

Research Associate – Skin Inflammation and Carcinogenesis (Imperial College London)

Postdoctoral Scientist – Skin Microbiome (National Human Genome Research Institute)

Senior Manager Immunology – Immunology (Baxalta Innovations GmbH)

Assistant Professor – Cell Biology or Molecular and Cellular Mechanisms (Washington University School of Medicine)

PhD Position – Materials Engineering (IFP Energies Nouvelles)

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