DERMAL STEM CELLS & TISSUE REGENERATION Differential Features Between Chronic Skin Inflammatory Diseases Revealed in Skin-Humanized Psoriasis and Atopic Dermatitis Mouse Models The authors described and characterized an animal model for atopic dermatitis using similar bioengineered-based approaches, by intradermal injection of human T helper type 2 lymphocytes in regenerated human skin after partial removal of stratum corneum. [J Invest Dermatol] Abstract Hypermethylation of the Keap1 Gene Inactivates Its Function, Promotes Nrf2 Nuclear Accumulation, and Is Involved in Arsenite-Induced Human Keratinocyte Transformation By establishing transformed human keratinocyte cells via chronic arsenite treatment, researchers observed a continuous reduction in reactive oxygen species levels and enhanced levels of nuclear factor E2-related factor 2 (Nrf2) and its target antioxidant enzymes in the later stage of arsenite-induced cell transformation. [Free Radic Biol Med] Abstract Hair Follicle and Interfollicular Epidermal Stem Cells Make Varying Contributions to Wound Regeneration By comparing the fates of several keratinocyte lineages, scientists observed an initial decrease in both hair follicle- and interfollicular epidermis-derived cells within the transient acanthotic layers of the regenerating epithelium. [Cell Cycle] Abstract The Proteasome Immunosubunits, PA28 and ER-Aminopeptidase 1 Protect Melanoma Cells from Efficient MART-126-35 Specific T-Cell Recognition Researchers demonstrated that the IFN-γ-inducible proteasome subunit β2i/MECL-1, proteasome activator PA28 and ER-resident aminopeptidase ERAP1 impair MART-126-35 epitope generation. [Eur J Immunol] Abstract The Wound Healing and Antibacterial Activity of Five Ethnomedical Calophyllum inophyllum Oils: An Alternative Therapeutic Strategy to Treat Infected Wounds Using cell and bacteria cultures, investigators confirmed the pharmacological effects of Calophyllum inophyllum oil (CIO) as wound healing and antimicrobial agent. They showed that the concentration of CIO needed to exhibit therapeutic effects are lower than concentrations exhibiting cytotoxic effects in vitro. [PLoS One] Full Article Pharmacological Activation of Estrogen Receptors-α and -β Differentially Modulates Keratinocyte Differentiation with Functional Impact on Wound Healing Investigators revealed that the HaCaT keratinocytes expressed both estrogen receptor (ER)-α and ‑β, and thus are well-suited for studying the effects of ER agonists on epidermal regeneration. [Int J Mol Med] Abstract | Download Full Article SKIN CANCERS & DISORDERS GLUT10 Deficiency Leads to Oxidative Stress and Non-Canonical αvβ3 Integrin-Mediated TGFβ Signaling Associated with Extracellular Matrix Disarray in Arterial Tortuosity Syndrome Skin Fibroblasts To discern the molecular mechanisms underlying the arterial tortuosity syndrome etiology, scientists performed gene expression profiling and biochemical studies on skin fibroblasts. Transcriptome analyses revealed the dysregulation of several genes involved in TGFβ signaling and extracellular matrix homeostasis as well as the perturbation of specific pathways that control both the cell energy balance and the oxidative stress response. [Hum Mol Genet] Abstract | Graphical Abstract Lysyl Hydroxylase 3 Localizes to Epidermal Basement Membrane and Is Reduced in Patients with Recessive Dystrophic Epidermolysis Bullosa The authors identified a significant decrease in PLOD3 expression and its encoded protein, the collagen modifying enzyme lysyl hydroxylase 3, in recessive dystrophic epidermolysis bullosa. [PLoS One] Full Article A Novel Adamantyl Benzylbenzamide Derivative, AP736, Inhibits Melanogenesis in B16F10 Mouse Melanoma Cells via Glycogen Synthase Kinase 3β Phosphorylation The authors investigated the novel candidate compound, AP736 (an adamantyl benzylbenzamide derivative), and its effects on melanogenesis in B16F10 melanoma cells, as well as the mechanisms involved. [Int J Mol Med] Abstract |