DERMAL STEM CELLS & TISSUE REGENERATION Gene Expression Profiling Reveals the Role of RIG1 Like Receptor Signaling in p53 Dependent Apoptosis Induced by PUVA in Keratinocytes To study in detail the molecular mechanism of UVA radiation (PUVA) in keratinocytes, scientists investigated the genome wide transcriptomic changes using Illumina whole genome gene expression beadchip. They demonstrated that miR-4516 mediated down-regulation of UBE2N promotes p53 nuclear translocation and pro-apoptotic activity of PUVA is independent of IRF3 but is mediated by the retinoic acid inducible gene-I (RIG-I) in a p53 and NFκB dependent manner. [Cell Signal] Abstract Alocasia denudata Engler Treatment Enhance Open Wound Healing Activities in Wistar Rat’s Skin The authors determined A. denudata treatment effects on open wound healing activities in Wistar rat’s skin. They showed that wounds treated with A. denudata stem juice possess a significantly higher rate of wound contraction, total protein concentration, hexosamine concentration and uronic acid concentration. [J Ethnopharmacol] Abstract Methotrexate Normalized Keratinocyte Activation Cycle by Overturning Abnormal Keratins as Well as Deregulated Inflammatory Mediators in Psoriatic Patients Researchers found the pharmacological effect of methotrexate on abnormal keratin and deregulated inflammatory mediators. [Clin Chim Acta] Abstract Ibuprofen Loaded PLA Nanofibrous Scaffolds Increase Proliferation of Human Skin Cells In Vitro and Promote Healing of Full Thickness Incision Wounds In Vivo In vitro cytotoxicity to human epidermal keratinocytes and human dermal fibroblasts of the three scaffolds with varying ibuprofen concentrations were evaluated and compared to pure polylactic acid (PLA) nanofibrous scaffolds. [J Biomed Mater Res B Appl Biomater] Abstract SKIN CANCERS & DISORDERS Evolution of Metastasis Revealed by Mutational Landscapes of Chemically Induced Skin Cancers Investigators used whole-exome sequencing of 103 matched benign, malignant and metastatic skin tumors from genetically heterogeneous mice to demonstrate that most metastases disseminate synchronously from the primary tumor, supporting parallel rather than linear evolution as the predominant model of metastasis. [Nat Med] Abstract The Homeoprotein DLX3 and Tumor Suppressor p53 Co-Regulate Cell Cycle Progression and Squamous Tumor Growth The authors report on a novel DLX3-dependent network that constrains epidermal hyperplasia and squamous tumorigenesis. [Oncogene] Abstract TGF-β-Induced Transcription Sustains Amoeboid Melanoma Migration and Dissemination The authors found that amoeboid melanoma cells are enriched in a transforming growth factor β (TGFβ)-driven signature. They observed that downstream of TGF-β, SMAD2 and its adaptor CITED1 control amoeboid behavior by regulating the expression of key genes that activate contractile forces. [Curr Biol] Full Article | Graphical Abstract Transcription Factor LSF (TFCP2) Inhibits Melanoma Growth Researchers found decreased expression level of late SV40 factor 3 in skin melanoma compared to that in benign melanocytic tumors and nevi in mice and humans. [Oncotarget] Full Article |