DERMAL STEM CELLS & TISSUE REGENERATION Injectable and Thermosensitive Soluble Extracellular Matrix and Methylcellulose Hydrogels for Stem Cell Delivery in Skin Wounds Scientists report a thermosensitive hydrogel composed of soluble extracellular matrix and methylcellulose for injectable stem cell delivery. [Biomacromolecules] Abstract S100A8 and S100A9 Are Induced by Decreased Hydration in the Epidermis and Promote Fibroblast Activation and Fibrosis in the Dermis The authors showed that reduced hydration increases the expression of S100 protein family members, S100A8/S100A9, in stratified keratinocyte culture and human ex vivo skin culture. [Am J Pathol] Abstract Platelets Regulate the Migration of Keratinocytes via Podoplanin/CLEC-2 Signaling during Cutaneous Wound Healing in Mice Investigators evaluated the effect of podoplanin expression levels on keratinocyte motility using cultured primary normal human epidermal keratinocytes. [Am J Pathol] Abstract A Comparative Analysis of Gene Expression Profiles during Skin Regeneration in Mus and Acomys Scientists performed an extensive comparison of gene expression profiles in response to 8mm full-thickness excisional wounds at days 3, 5, 7 and 14 post-wounding between Acomys and Mus to characterize differences in wound healing, and identify mechanisms involved in scar-free healing. [PLoS One] Full Article Effect of Microtubule-Associated Protein-4 on Epidermal Cell Migration under Different Oxygen Concentrations The authors showed that under hyperoxic and hypoxic conditions, HaCaT cells were able to regulate cell microtubule dynamics by microtubule-associated protein (MAP4), thus promoting cell migration. MAP4 silencing through targeted shRNA attenuated HaCaT cell migration under the above oxygen concentrations. [J Dermatol] Abstract SKIN CANCERS & DISORDERS Strand-Specific In Vivo Screen of Cancer-Associated miRNAs Unveils a Role for miR-21∗ in SCC Progression Focusing on miRs and/or miR∗s abundant in squamous cell carcinoma (SCC) stem cells, researchers engineered an efficient, strand-specific expression library, and apply functional genomics screening in mice to identify which of 169 cancer-associated miRs are key drivers in malignant progression. [Nat Cell Biol] Abstract Hydrogen Sulfide-Induced Itch Requires Activation of Cav3.2 T-Type Calcium Channel in Mice Researchers investigated the roles of hydrogen sulfide (H2S), a ubiquitous gasotransmitter, in itch signaling. They found that intradermal injection of H2S donors NaHS or Na2S, but not GYY4137, dose-dependently induced scratching behavior in a μ-opioid receptor-dependent and histamine-independent manner in mice. [Sci Rep] Full Article Impact of Oncogenic BRAF Mutations and p16 Expression on the Growth Rate of Early Melanomas and Nevi In Vivo The expression of BRAFV 600E and the loss of p16 accelerated the growth rate of early melanomas in vivo but not in melanocytic nevi. [Br J Dermatol] Abstract |