Dermal Cell News Volume 10.01 | Jan 15 2024

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    2024-01-15 | DCN 10.02


    Dermal Cell News by STEMCELL Technologies
    Vol. 10.01 – 15 January, 2024
    TOP STORY

    Hierarchical Double-Layer Microneedles Accomplish Multicenter Skin Regeneration in Diabetic Full-Thickness Wounds

    Investigators prepared a novel multi-island double-layer microneedle using gelatin-methacryloylchitosan, which was loaded with keratinocytes and dermal fibroblasts.
    [Journal Of Advanced Research]

    Full ArticleGraphical Abstract
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    Bioassembly of Multicellular Spheroids to Mimic Complex Tissue Structure Using Surface-Modified Magnetized Nanofibers

    The authors generated magnetized nanofibers by electrospinning magnetic nanoparticles dispersed in poly-L-lactic acid solution, which were then coated with polydopamine (PD). These PD-coated magnetic fibers had magnetic-responsive properties when incorporated into human dermal fibroblast spheroids.
    [Biofabrication]

    Full Article

    PDMS Nanoparticles-Decorated PDMS Substrate Promotes Adhesion, Proliferation and Differentiation of Skin Cells

    Scientists proposed to coat polydimethylsiloxane (PDMS) nanoparticles on the surface of PDMS film to improve adhesion, proliferation and differentiation of skin cells.
    [Journal Of Colloid And Interface Science]

    AbstractGraphical Abstract

    Single-Cell Sequencing Reveals Increased LAMB3-Positive Basal Keratinocytes and ZNF90-Positive Fibroblasts in Autologous Cultured Epithelium

    Researchers cultured autologous epithelium under serum- and feeder-free (SFF) conditions, comparing its safety and efficacy with serum- and feeder-dependent (SFD) conditions in stable vitiligo patients.
    [Communications Biology]

    Full Article

    Application of Bacteriophage φPaP11-13 Attenuates Rat Cutibacterium acnes Infection Lesions by Promoting Keratinocytes Apoptosis via Inhibiting PI3K/Akt Pathway

    The authors found that rats infected with C. acnes had higher average ear thickness, greater enrichment of inflammatory cells as shown by hematoxylin–eosin staining, and fewer TdT-mediated dUTP Nick-End Labeling-positive keratinocytes visualized by IF staining.
    [Microbiology Spectrum]

    Full Article

    Novel Cellular Systems Unveil Mucosal Melanoma Initiating Cells and a Role for PI3K/Akt/mTOR Pathway in Mucosal Melanoma Fitness

    Five novel cell lines were obtained from patient-derived biopsies of mucosal melanomas (MM) arising in the sino-nasal mucosa and designated as SN-MM1-5. The morphology, ultrastructure and melanocytic identity of SN-MM cell lines were validated by transmission electron microscopy and immunohistochemistry.
    [Journal Of Translational Medicine]

    Full Article

    Profibrotic Subsets of SPP1+ Macrophages and POSTN+ Fibroblasts Contribute to Fibrotic Scarring in Acne Keloidalis

    Cell communication analyses indicated that fibroblasts and myeloid cells communicated by SPP1 signaling networks in lesional skin.
    [Journal Of Investigative Dermatology]

    Abstract

    Functional Characterization of the Dimeric Form of PDGF-Derived Fusion Peptide Fabricated Based on Theoretical Arguments

    Scientists designed a new peptide-derived platelet-derived growth factors (PDGFs)-BB,which was expressed in the Shuffle strain of E. coli, and purified by Ni-NTA agarose affinity column chromatography. The effect of this fusion peptide was evaluated on L929 fibroblast cells and animal models with skin lesions.
    [Scientific Reports]

    Full Article
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    REVIEWS

    Tumor-Infiltrating Lymphocyte Cancer Therapy Nears FDA Finish Line

    The FDA could soon approve Iovance’s lifileucel for advanced melanoma, a much-anticipated milestone for the 35-year-old T cell therapy modality.
    [Nature Reviews Drug Discovery]

    Full Article

    Status of Research on the Development and Regeneration of Hair Follicles

    The authors investigate the mechanisms underlying hair follicle (HF) development and regeneration. They study the structure, development, cycle, and cellular function of HFs.
    [International Journal Of Medical Sciences]

    Full Article
    INDUSTRY AND POLICY NEWS

    This Is the Oldest Skin Ever Found

    Nearly 300-million-year-old fossilized reptile skin found in Oklahoma cave resembles that of modern crocodiles.
    [Science Insider]

    News Article
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    JOB OPPORTUNITIES

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    Northwestern University – Chicago, Illinois, United States

    PhD Positions – Tissue Regeneration and Cancer Immunotherapy

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