 | | Vol. 10.02 – 22 January, 2024 |
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| To investigate whether black phosphorus nanosheets have positive bio-effects on in situ skin repair, the authors verified black phosphorus nanosheets’ positive effects on angiogenic and anti-inflammatory abilities in vitro.
[ACS Nano] |
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| PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
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| ScRNA-seq identified a specific touch dome keratinocyte marker, Tenascin-C (TNC). Lineage tracing of Tnc-expressing touch dome keratinocytes revealed that these cells maintained themselves as an autonomous epidermal compartment and gave rise to Merkel cells upon injury.
[Science Advances] |
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| Researchers conducted a comprehensive study to assess the effectiveness of metformin and adipose-derived stem cells, whether autologous or allogeneic, individually or in combination therapy, in mitigating radiation-induced skin fibrosis.
[Stem Cell Research & Therapy] |
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| The experiments used human bone marrow mesenchymal stem cells from the American Type Culture Collection, an in vivo mouse model of diabetes to assess wound healing, as well as the human keratinocyte HaCaT cell line.
[Burns & Trauma] |
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| The authors showed that Bmal1 has a context-dependent role in mouse melanoma tumor growth. Loss of Bmal1 in YUMM2.1 or B16-F10 melanoma cells eliminated clock function and diminished hypoxic gene expression and tumorigenesis.
[Nature Communications] |
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| Investigators reported a comprehensive spatial atlas of adult human skin across different anatomical sites and basal cell carcinoma — the most common form of skin cancer—encompassing in vivo optical coherence tomography, scRNAseq, global spatial transcriptomic profiling, and in situ sequencing.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Scientists presented a computational model, pyroptosis-related gene score, or PScore, to assess pyroptosis status. They applied PScore to 1388 melanoma samples in amn in-house cohort and eight other publicly available independent cohorts.
[BMC Medicine] |
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| Investigators found that the protein kinase RNA-like ER kinase branch of unfolded protein response was confirmed to be responsible for the overexpression and membranal translocation of calreticulin in melanocytes under oxidative stress.
[Journal Of Investigative Dermatology] |
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| Scientists investigated the molecular mechanisms through which α-synuclein and DJ-1 interact, suggesting novel biomarkers and targets in melanoma.
[Cancer Medicine] |
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| The authors summarize the current update on IL-36 cytokines in inflammatory skin diseases.
[Journal Of Investigative Dermatology] |
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| The US Environmental Protection Agency (EPA) has abandoned a controversial plan to phase out all use of mammals to test the safety of chemicals by 2035. The hard deadline—imposed in 2019 to accelerate a move toward nonanimal models such as computer programs and “organs on a chip”—made EPA unique among US federal agencies.
[Science Insider] |
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| March 18 – 19, 2024
London, England, United Kingdom |
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| | University Hospital of Muenster – MĂĽnster, Germany |
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| | Karolinska Institutet – Solna, Sweden |
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| | University of Birmingham – Birmingham, England, United Kingdom |
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| | Northwestern University – Chicago, Illinois, United States |
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| | Albert-Ludwigs-University Freiburg – Freiburg im Breisgau, Germany |
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