Dermal Cell News Volume 10.03 | Jan 29 2024

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    2024-01-29 | DCN 10.03


    Dermal Cell News by STEMCELL Technologies
    Vol. 10.03 – 29 January, 2024
    TOP STORY

    Sexual Dimorphism in Melanocyte Stem Cell Behavior Reveals Combinational Therapeutic Strategies for Cutaneous Repigmentation

    Scientists identified unique melanocyte stem cell epidermal migration rates between male and female mice, which was due to sexually dimorphic cutaneous inflammatory responses generated by ultra-violet B exposure.
    [Nature Communications]

    Full Article
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    Generating Dual Structurally and Functionally Skin-Mimicking Hydrogels by Crosslinking Cell-Membrane Compartments

    The crosslinked network was formed via free radical polymerization using olefinic double bond-functionalized extracellular vesicles as a crosslinker.
    [Nature Communications]

    Full Article

    A Sustainable Strategy for Generating Highly Stable Human Skin Equivalents Based on Fish Collagen

    The fortified fish collagen formulation was optimized to enable reproducible fabrication of full-thickness human skin equivalents that underwent limited contraction, facilitating the incorporation of human donor-derived skin cells and formation of biomimetic dermal and epidermal layers.
    [Biomaterials Advances]

    Abstract

    Mechanical Stiffness Promotes Skin Fibrosis via Piezo1-Wnt2/Wnt11-CCL24 Positive Feedback Loop

    Investigators reported a positive feedback loop mediated by the mechanosensitive ion channel Piezo1 and aberrant tissue mechanics in driving skin fibrosis.
    [Cell Death & Disease]

    Full Article

    Live Tracking of Basal Stem Cells of the Epidermis during Growth, Homeostasis and Injury Response in Zebrafish

    Scientists reported that zebrafish integrin beta 4 was a useful marker for basal cell labelling, irrespective of the body region, stage and regenerative status.
    [Development]

    Abstract

    Tumor Cell–Intrinsic PD-1 Promotes Merkel Cell Carcinoma Growth by Activating Downstream mTOR-Mitochondrial ROS Signaling

    In human Merkel cell carcinoma lines and clinical tumors, RT-PCR–based sequencing, immunoblotting, flow cytometry, and immunofluorescence analyses demonstrated PD-1 gene and protein expression by Merkel cell carcinoma cells.
    [Science Advances]

    Full ArticlePress Release

    High UV Damage and Low Repair, but Not Cytosine Deamination, Stimulate Mutation Hotspots at ETS Binding Sites in Melanoma

    Researchers used UV damage sequencing data and analyzed cyclobutane pyrimidine dimer formation, DNA repair, and cyclobutane pyrimidine dimer deamination in human cells at single-nucleotide resolution.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Abstract

    LPCAT1 Facilitates Keratinocyte Hyperproliferation and Skin Inflammation in Psoriasis via Regulating GLUT3

    Lysophosphatidylcholine acyltransferase 1 (LPCAT1) promoted keratinocyte hyperproliferation and enhanced the secretion of IL-1β, IL-6, CXCL10, CCL20, S100A9, and platelet-activating factor.
    [Journal Of Investigative Dermatology]

    Abstract

    Extracellular Lipidosomes Containing Lipid Droplets and Mitochondria Are Released during Melanoma Cell Division

    Investigators reported a new type of large CD133+ extracellular vesicles released by metastatic FEMX-I melanoma cells.
    [Cell Communication And Signaling]

    Full Article
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    REVIEWS

    Single-Cell RNA Sequencing in Melanoma: What Have We Learned So Far?

    The authors examine the concept of intratumoral heterogeneity and the challenges it poses to achieving long-lasting treatment responses, and focus on the significance of next generation single-cell sequencing in advancing our understanding of melanoma diversity and the unique insights gained from single-cell studies.
    [eBioMedicine]

    Full Article
    INDUSTRY AND POLICY NEWS

    Open-Access Papers Draw More Citations from a Broader Readership

    Researchers report that open-access papers have a greater reach than paywalled ones in two key ways: They attract more total citations, and those citations come from scholars in a wider range of locations, institutions, and fields of research.
    [ScienceInsider]

    Editorial
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