Dermal Cell News Volume 10.06 | Feb 26 2024

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    Jamie Kang
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    2024-02-26 | DCN 10.06


    Dermal Cell News by STEMCELL Technologies
    Vol. 10.06 – 26 February, 2024
    TOP STORY

    Adjuvant Dendritic Cell Therapy in Stage IIIB/C Melanoma: The MIND-DC Randomized Phase III Trial

    In this Phase III clinical trial, 148 patients with resected stage IIIB/C melanoma were randomized to adjuvant treatment with natural dendritic cells (nDCs) or placebo. Active treatment consisted of intranodally injected autologous CD1c+ conventional and plasmacytoid DCs loaded with tumor antigens.
    [Nature Communications]

    Full Article
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    CXCL12+ Dermal Fibroblasts Promote Neutrophil Recruitment and Host Defense by Recognition of IL-17

    Investigators performed an unbiased network analysis of mouse skin during invasive S. aureus infection and revealed a dominant role for CXCL12+ fibroblast subsets in neutrophil communication.
    [Journal Of Experimental Medicine]

    Abstract

    LIGHT Signaling through LTβR and HVEM in Keratinocytes Promotes Psoriasis and Atopic Dermatitis-Like Skin Inflammation

    Scientists showed that tumor necrosis factor superfamily member 14 (TNFSF14), known as LIGHT, was required for experimental psoriasis, similar to its requirement in experimental atopic dermatitis.
    [Journal Of Autoimmunity]

    Abstract

    Biofabrication of Biomimetic Undulating Microtopography at the Dermal-Epidermal Junction and Its Effects on the Growth and Differentiation of Epidermal Cells

    A composite manufacturing method including electrospinning, 3D printing, and functional coating was developed to produce the epidermal models with rete ridges. Polycaprolactone nanofibers were firstly electrospun to mimic the extracellular matrix environment and be responsible for cell attachment.
    [Biofabrication]

    Abstract

    In Vivo and In Vitro Wound Healing and Tissue Repair Effect of Trametes versicolor Polysaccharide Extract

    Researchers evaluated the wound healing characteristics of Trametes versicolor. Anti-oxidant activity addressed by employing the 2,2-diphenyl-1-picrylhydrazyl assay resulting 53.7% inhibitory effect.
    [Scientific Reports]

    Abstract

    HMGA1 Drives Chemoresistance in Esophageal Squamous Cell Carcinoma by Suppressing Ferroptosis

    Investigators demonstrated that ferroptosis triggered by inhibiting high mobility group AT-hook 1 (HMGA1) may provide a novel opportunity to gain an effective therapeutic strategy against chemoresistance in esophageal squamous cell carcinoma.
    [Cell Death Discovery]

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    REVIEWS

    Review: Are Moles Senescent?

    The authors review these areas, along with the genetic, biological, and molecular evidence supporting senescence in melanocytic nevi.
    [Pigment Cell & Melanoma Research]

    Full Article
    INDUSTRY AND POLICY NEWS

    MediWound Announces Positive Results in Head-to-Head Comparison of EscharEx® vs. SANTYL® within the ChronEx Phase II Randomized Controlled Study

    MediWound, Ltd. announced the results of head-to-head comparison analyses of EscharEx, the company’s lead asset in development for chronic wounds, to collagenase SANTYL ointment, approved by the FDA for debriding chronic dermal ulcers.
    [MediWound, Ltd.]

    Press Release
    FEATURED EVENT

    AACR Annual Meeting 2024

    April 7 – 10, 2024
    San Diego, California, United States

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    JOB OPPORTUNITIES

    Postdoctoral Fellowship – Skin Research

    Office of Women’s Health Grant Program – Jefferson, Arkansas, United States

    Postdoctoral Fellow – Biochemistry and Molecular Biology

    Augusta University – Augusta, Georgia, United States

    Senior Technician – Aging of Human Skin

    University of Michigan – Ann Arbor, Michigan, United States

    Department Chair – Cell Biology and Human Anatomy

    UC Davis – Davis, California, United States

    Postdoctoral Scientists – Molecular Basis of Cancer

    Cyprus Cancer Research Institute – Aglandjia, Cyprus

    > See All Jobs

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