Dermal Cell News Volume 10.07 | Mar 4 2024

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    2024-03-04 | DCN 10.07


    Dermal Cell News by STEMCELL Technologies
    Vol. 10.07 – 4 March, 2024
    TOP STORY

    3D Modeling of Normal Skin and Cutaneous Squamous Cell Carcinoma. A Comparative Study in 2D Cultures, Spheroids, and 3D Bioprinted Systems

    Scientists developed an innovative in vitro human three-dimensional (3D) normal skin model and a multicellular model of human cutaneous squamous cell carcinoma using 3D bioprinting technology.
    [Biofabrication]

    Full Article
    Try proven workflows for your hPSC culture. Click to request your offer now.
    PUBLICATIONSRanked by the impact factor of the journal

    Oct4 Is a Gatekeeper of Epithelial Identity by Regulating Cytoskeletal Organization in Skin Keratinocytes

    Investigators generated OCT4 knockout clonal cell lines using immortalized human skin keratinocytes to identify a functional role for the protein.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Gasdermin E Promotes Translocation of p65 and c-Jun into Nucleus in Keratinocytes for Progression of Psoriatic Skin Inflammation

    Through analysis of GEO datasets, scientists found elevated Gasdermin E (GSDME) levels in psoriatic lesional skin. Additionally, GSDME levels correlated with both psoriasis severity and response to biologics treatments.
    [Cell Death & Disease]

    Full ArticleGraphical Abstract

    Cinnamic Acid Promotes Elongation of Hair Peg-Like Sprouting in Hair Follicle Organoids via Oxytocin Receptor Activation

    Treatment with cinnamic acid led to upregulation of oxytocin receptor and trichogenic gene expression in human dermal papilla cells.
    [Scientific Reports]

    Full Article

    PIKFYVE Inhibitors Trigger Interleukin-24-Dependent Cell Death of Autophagy-Dependent Melanoma

    Autophagy-dependent melanoma cells were compared with normal foreskin fibroblasts to elucidate the mechanism by which 1-phosphatidylinositol 3-phosphate 5-kinase (PIKFYVE) inhibition induced cell death.
    [Molecular Oncology]

    Full Article

    Daturataturin A Ameliorates Psoriasis by Regulating PPAR Pathway

    Researchers established a daturataturin A (DTA) psoriasis-like keratinocytes model by stimulating HaCaT cells with M5 cocktail cytokines including interleukin (IL)-17A, IL-22, oncostatin M, IL-1α, and tumor necrosis factor-α, followed by intervention with DTA.
    [Biochemical Genetics]

    Abstract
    March 2024 Science Events
    REVIEWS

    Dormancy of Cutaneous Melanoma

    The authors focus on the mechanisms regulating the initiation of cutaneous melanoma dormancy as well as those that are involved in the reawakening of dormant cutaneous melanoma cells.
    [Cancer Cell International]

    Full Article
    INDUSTRY AND POLICY NEWS

    New Breakthrough Therapy for Metastatic Melanoma Receives FDA Approval

    A first-of-its-kind cellular immunotherapy pioneered at Moffitt Cancer Center is now available for patients with advanced melanoma. It’s called TIL, short for tumor-infiltrating lymphocyte therapy. The one-time T-cell therapy infusion uses a patient’s own immune cells to fight their cancer.
    [Moffitt Cancer Center]

    Press Release
    FEATURED EVENT

    2nd International Conference on Cancer and Oncology Research

    April 15 – 16, 2024
    London, England, United Kingdom

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Researcher – Skin Development, Wound Healing, & Cancer

    University of Texas Southwestern Medical Center – Dallas, Texas, United States

    Postdoctoral Scientists – Molecular Basis of Cancer

    Cyprus Cancer Research Institute – Aglandjia, Cyprus

    Department Chair – Cell Biology and Human Anatomy

    UC Davis – Davis, California, United States

    Senior Technician – Aging of Human Skin

    University of Michigan – Ann Arbor, Michigan, United States

    Postdoctoral Fellow – Biochemistry and Molecular Biology

    Augusta University – Augusta, Georgia, United States

    > See All Jobs

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