 | | Vol. 10.10 – 15 April, 2024 |
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| The authors reported that a self-pumping organohydrogel dressing, prepared by a three-dimensional-templated wetting-enabled-transfer polymerization process, could efficiently drain viscous fluids and accelerate diabetic wound healing.
[Advanced Materials] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
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| Scientists constructed a microdot biomaterial system, which released functionalized polypeptides targeting mitochondria and promoted the influx of extracellular calcium ions under the inflammatory environment, thus inhibiting the expression of N-cadherin mediating cell-cell interaction.
[Advanced Materials] |
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| The authors introduced a double-network conductive eutectogel, simulating the conductivity and mechanical strength of natural human skin. When combined with exogenous electrical stimulation, the eutectogel exhibited the ability to reduce inflammation and facilitate skin tissue remodeling.
[Advanced Healthcare Materials] |
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| Researchers demonstrated that kindlin-3 inactivation through knockdown or somatic mutations increased BRAFV600mut melanoma cells oncogenic properties via collagen-related signaling by decreasing cell adhesion and enhancing proliferation and migration in vitro, and by promoting tumor growth in mice.
[Oncogene] |
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| Investigators showed that steroid receptor RNA activator-like non-coding RNA (SLNCR1) was significantly up-regulated in human malignant melanoma tissues and cell lines and functioned as an oncogene.
[Cell Death Discovery] |
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| Scientists established a xenograft model of human melanoma that spontaneously metastasized to lymph nodes and lungs. This model allowed precise monitoring of melanoma progression, and was suitable for the quantitative and qualitative analysis of circulating tumor cells.
[Scientific Reports] |
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| Researchers investigated the role of the podoplanin-platelet C-type lectin-like receptor 2 (CLEC-2) interaction in melanoma pulmonary metastasis, and reported that the platelet Syk-dependent signaling pathway contributed to platelet aggregation and melanoma metastasis.
[BMC Cancer] |
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| The authors discuss the role of melanocytes in homeostasis and disease, before discussing their potential in regenerative medicine applications, such as for disease modeling, drug testing, or therapy development using stem cell technologies, tissue engineering, and extracellular vesicles.
[Journal Of Translational Medicine] |
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| Achilles Therapeutics announced interim Phase I/IIa data on the use of clonal neoantigen reactive T cells from the CHIRON study in advanced unresectable or metastatic non-small cell lung cancer, and the THETIS study in recurrent or metastatic malignant melanoma.
[Achilles Therapeutics] |
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| May 29 – June 1, 2024
Vancouver, British Columbia, Canada |
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| | University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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| | University of Luxembourg – Esch-sur-Alzette, Luxembourg |
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| | Boston University – Boston, Massachusetts, United States |
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| | Karolinska Institute – Solna, Sweden |
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| | University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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