Dermal Cell News Volume 10.11 | April 29 2024

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    2024-04-29 | DCN 10.11


    Dermal Cell News by STEMCELL Technologies
    Vol. 10.11 – 29 April, 2024
    TOP STORY

    Skin Graft with Dermis and Appendages Generated In Vivo by Cell Competition

    Scientists generated complete skin grafts with pluripotent stem cell-derived epidermis with appendages on p63 knockout embryos’ dermis.
    [Nature Communications]

    Full Article
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    PUBLICATIONSRanked by the impact factor of the journal

    TANGO1 Inhibitors Reduce Collagen Secretion and Limit Tissue Scarring

    Investigators designed membrane permeant peptide inhibitors that specifically targeted the primary interface between TANGO1 and cTAGE5, an interaction that was required for collagen export from endoplasmic reticulum exit sites.
    [Nature Communications]

    Full Article

    Ribosomal S6 Kinase 2-Forkhead Box Protein O4 Signaling Pathway Plays an Essential Role in Melanogenesis

    The authors reported that α-melanocyte-stimulating hormone acted as a major stimulus of melanogenesis in melanoma cells.
    [Scientific Reports]

    Full Article

    Exploring the Mechanism of Huanglian Ointment in Alleviating Wound Healing after Anal Fistula Surgery through Metabolomics and Proteomics

    S. aureus infected wounds in rats were used to imitate poor healing wounds after anal fistula surgery to investigate the mechanism of Huanglian ointment on wound healing.
    [Heliyon]

    Full Article

    Lysophosphatidic Acid Down-Regulates Human RIPK4 mRNA in Keratinocyte-Derived Cell Lines

    A serum-derived phospholipid, lysophosphatidic acid (LPA), was identified as an important biologic inhibitor of receptor interacting protein kinase 4 (RIPK4). LPA functioned by inhibiting the transcription of RIPK4 mRNA.
    [PLOS One]

    Full Article

    The Involvement of RIPK4 in TNF-α-Stimulated IL-6 and IL-8 Production by Melanoma Cells

    The authors examined the effects of receptor-interacting protein kinase (RIPK4) downregulation on the transcriptomic profile of melanoma, and revealed a complex role for RIPK4 in regulating the immune signaling network in melanoma cells.
    [Journal Of Cancer Research And Clinical Oncology]

    Full Article
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    REVIEWS

    Cell Death as an Architect of Adult Skin Stem Cell Niches

    Investigators described how regulated cell death modalities functionally affect epidermal stem cell niches along with their relevance to injury repair, inflammatory skin disorders, and cancer.
    [Cell Death & Differentiation]

    Full Article

    Lipid-Based Nanoparticles as a Promising Treatment for the Skin Cancer

    Scientists examine the properties and applications of nanoliposomes used in the treatment and prevention of numerous types of skin cancer.
    [Heliyon]

    Full Article
    INDUSTRY AND POLICY NEWS

    Dermavant Announces FDA Acceptance of Supplemental New Drug Application (sNDA) for VTAMA® (Tapinarof) Cream, 1% for the Treatment of Atopic Dermatitis in Adults and Children 2 Years of Age and Older

    Dermavant Sciences, Inc. announced that the US FDA accepted the company’s sNDA for VTAMA® cream, 1% for the topical treatment of atopic dermatitis in adults and children two years of age and older.
    [Dermavant Sciences, Inc.]

    Press Release
    FEATURED EVENT

    2024 ASCO Annual Meeting

    May 31 – June 4, 2024
    Chicago, Illinois, United States & Online

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    JOB OPPORTUNITIES

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    University of Cambridge – Cambridge, England, United Kingdom

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    Virginia Tech – Blacksburg, Virginia, United States

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    University of Pittsburgh – Pittsburgh, Pennsylvania, United States

    Research Technician – Biological Sciences

    University of Luxembourg – Esch-sur-Alzette, Luxembourg

    Postdoctoral Researcher – Scleroderma

    Boston University – Boston, Massachusetts, United States

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