Dermal Cell News Volume 17.18 | May 17 2021

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    Dermal Cell News by STEMCELL Technologies
    Vol. 7.18 – 17 May, 2021
    TOP STORY

    Ultraviolet
    Light-Induced Collagen Degradation Inhibits Melanoma Invasion

    Scientists confirmed UVR-damaged fibroblasts persistently upregulated collagen-cleaving matrix metalloprotein-1 (MMP1) expression, reducing local collagen (COL1A1), and COL1A1 degradation by MMP1 decreased melanoma invasion.
    [Nature Communications]

    Full Article

    Research Is Challenging. Learning to Culture Cells Shouldn't Be. Attend Training
    PUBLICATIONSRanked by the impact factor of the journal
    DERMAL STEM CELLS & TISSUE REGENERATION

    UVB Protective Effects of Sargassum horneri
    through the Regulation of Nrf2 Mediated Antioxidant Mechanism

    Investigators aimed to evaluate the protective effect of a methanol extract of Sargassum horneri, which contained 6-hydroxy-4,4,7a-trimethyl-5,6,7,7a-tetrahydrobenzofuran-2(4H)-one and apo-9′-fucoxanthinone, against ultraviolet B (UVB)-induced cellular damage in human keratinocytes and its underlying mechanism.
    [Scientific Reports]

    Full Article

    Cellular Metabolism and IL-6 Concentrations during Stimulated Inflammation in Primary Fibroblasts from Small and Large Dog Breeds as They Age

    Scientists examined aerobic and glycolytic cellular metabolism, and IL-6 concentrations in primary fibroblast cells isolated from small and large dog breeds, that were either recently born puppies or old dogs after death.
    [Journal of Experimental Biology]

    Full Article

    SKIN CANCERS & DISORDERS

    The
    Endoribonuclease N4BP1 Prevents Psoriasis by Controlling Both Keratinocytes Proliferation and Neutrophil Infiltration

    Researchers found that the expression of NEDD4-binding protein 1 (N4BP1) in skin was highest among all 54 tested tissues, and its expression was further upregulated in psoriatic skin.
    [Cell Death & Disease]

    Full Article

    Unraveling
    the Role of microRNA/isomiR Network in Multiple Primary Melanoma Pathogenesis

    Scientists provided a putative and comprehensive characterization of the miRNA/isomiR regulatory network of multiple primary melanomas, highlighting mechanisms of tumor development and molecular features differentiating this subtype from single melanomas.
    [Cell Death & Disease]

    Full Article

    mGPDH
    Deficiency Leads to Melanoma Metastasis via Induced NRF2

    In vivo and in vitro experiments indicated that mGPDH depletion accelerated melanoma migration and invasion without affecting proliferation or apoptosis.
    [Journal of Cellular and Molecular Medicine]

    Full Article

    Effect
    of Hypoxia Factors Gene Silencing on ROS Production and Metabolic Status of A375 Malignant Melanoma Cells

    Researchers detected a significantly reduced A375 cell viability, an increase in alanine, inositol, nucleotides, and other metabolites that together define apoptosis.
    [Scientific Reports]

    Full Article

    Novel
    Curcumin-Resveratrol Solid Nanoparticles Synergistically Inhibit Proliferation of Melanoma Cells

    Scientists investigated the feasibility of a topical delivery system, using a solid lipid nanoparticles loaded delivery systems, that could enhance the skin penetration and anti-cancer efficacy of combination of these polyphenols.
    [Pharmaceutical Research]

    Abstract


    STAT3/SH3PXD2A-AS1/miR-125b/STAT3 Positive Feedback Loop Affects Psoriasis Pathogenesis via Regulating Human Keratinocyte Proliferation

    SH3PXD2A-AS1 silence was found to suppress HaCaT cell proliferation and promote HaCaT cell apoptosis significantly. Meanwhile, SH3PXD2A-AS1 silence significantly increased cleaved-caspase-3 protein levels and inhibited S100A7, TNF-α, IL-6, p-STAT3, STAT3, CyclinD1, and survivin protein levels.
    [Cytokine]

    Abstract

    Request a free copy of the Growing Organoids from Stem Cells Wallchart
    REVIEWS

    Virus-Mediated
    Inactivation of Anti-apoptotic Bcl-2 Family Members Promotes Gasdermin-E-dependent Pyroptosis in Barrier Epithelial Cells

    Scientists demonstrate that inhibition of protein synthesis during viral infection is sensed as a virulence strategy and initiates pyroptosis in human keratinocytes.
    [Immunity]

    AbstractGraphical Abstract

    Mechanisms
    of Microbe-Immune System Dialogue within the Skin

    The authors summarize the ongoing clinical studies that are targeting the microbiome in patients with skin disorders.
    [Genes & Immunity]

    Full Article

    INDUSTRY AND POLICY NEWS

    Incyte Announces Positive Results from Phase III TRuE-V Program Evaluating Ruxolitinib Cream in Patients with Vitiligo

    Incyte. Inc, announced positive topline results from its pivotal Phase III TRuE-V clinical trial program evaluating the safety and efficacy of ruxolitinib cream, an investigational, nonsteroidal, anti-inflammatory, JAK inhibitor, topical therapy, in adolescent and adult patients with vitiligo.
    [Incyte, Inc. (Business Wire, Inc.)]

    Press Release

    FEATURED EVENT

    Epithelial
    Stem Cells and Niches

    June 5 – 10, 2022
    Ventura, California, United States


    > See All Events

    JOB OPPORTUNITIES

    Principal Bioinformatician – Skin Cancers

    Wellcome Trust Sanger Institute – Cambridge, England, United Kingdom

    Group Leader – Skin Immunology

    University of Copenhagen – Copenhagen, Denmark

    Postdoctoral Fellow – Wound Healing

    UCLA – Los Angeles, California, United States

    Postdoctoral Fellow – Functional Genomics and Epigenomic Regulation

    National Institutes of Health – Bethesda, Maryland, United States

    Research Specialist – Skin Stem Cells

    Howard Hughes Medical Institute – New York, New York, United States

    >
    See All Jobs

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