DERMAL STEM CELLS & TISSUE REGENERATION Epidermal Notch1 Recruits RORγ+ Group 3 Innate Lymphoid Cells to Orchestrate Normal Skin Repair The authors showed that Notch1 works as a damage response signal. Epidermal Notch induced recruitment of immune cell subsets including RORγ+ ILC3s into wounded dermis; RORγ+ ILC3s were potent sources of IL17F in wounds and control immunological and epidermal cell responses. [Nat Commun] Full Article Knockdown of LncRNA-ATB Suppresses Autocrine Secretion of TGF-β2 by Targeting ZNF217 via miR-200c in Keloid Fibroblasts Researchers investigated the role of long non-coding RNA (lncRNA)-activated by transforming growth factor-β (TGF-β) (lncRNA-ATB) in the autocrine secretion of TGF-β in keloid fibroblasts and explored the underlying molecular mechanism. [Sci Rep] Full Article Skin Barrier Defects Caused by Keratinocyte-Specific Deletion of ADAM17 or EGFR Are Based on Highly Similar Proteome and Degradome Alterations Scientists aimed for the first proteomic/degradomic approach to characterize the disruption of the ADAM17–epidermal growth factor receptor (EGFR) signaling axis and its consequences for epidermal barrier formation. [J Proteome Res] Abstract | Graphical Abstract ILK–PI3K/AKT Pathway Participates in Cutaneous Wound Contraction by Regulating Fibroblast Migration and Differentiation to Myofibroblast Using in vitro studies, researchers demonstrated that integrin-linked kinase (ILK) and PI3K/AKT inhibitors suppressed the contraction of fibroblast-populated collagen lattices, inhibited fibroblast migration, and interrupted the effect of TGF-β1 on promoting alpha smooth muscle actin expression in fibroblasts. [Lab Invest] Abstract Modeling Fibrosis Using Fibroblasts Isolated from Scarred Rat Vocal Folds Given the importance of scar vocal fold fibroblasts (VFFs) to phenotypically appropriate in vitro modeling of VF fibrosis, investigators pursued detailed characterization of scar VFFs obtained from surgically injured rat VF mucosae, compared with those obtained from experimentally naïve, age-matched tissue. [Lab Invest] Abstract SKIN CANCERS & DISORDERS The Transcription Factor RUNX2 Regulates Receptor Tyrosine Kinase Expression in Melanoma Scientists demonstrated that RUNX2-deficient melanoma cells display a significant decrease in three receptor tyrosine kinases, EGFR, IGF-1R and PDGFRβ. [Oncotarget] Full Article Use of a MCL-1 Inhibitor Alone to De-Bulk Melanoma and in Combination to Kill Melanoma Initiating Cells Researchers examined the effects of the MCL-1 inhibitor SC-2001 in killing non melanoma-initiating-cells (bulk of melanoma), and melanoma-initiating-cells. [Oncotarget] Full Article TET2 Negatively Regulates Nestin Expression in Human Melanoma Investigators provide evidence suggesting that nestin regulation is negatively controlled epigenetically by translocation methylcytosine dioxygenase 2 (TET) 2 via 5-hydroxymethylcytosine binding at the 3′ untranslated region of the nestin gene, providing one potential pathway for understanding melanoma growth characteristics. [Am J Pathol] Abstract Transcription Factor 7-Like 1 Dysregulates Keratinocyte Differentiation through Upregulating Lipocalin 2 To reveal the potential role of transcription factor 7-like 1 (Tcf7l1) in the dysregulation of keratinocyte differentiation, both Tcf7l1 and lipocalin 2 (LCN2) were determined in a variety of skin disorders. Scientists found that both Tcf7l1 and LCN2 were highly expressed in diseases characterized by defective keratinocyte differentiation (especially psoriasis vulgaris, condyloma acuminatum, squamous cell carcinoma, etc.). [Cell Death Disc] Full Article |