Dermal Cell News Volume 2.20 | Jun 6 2016

TOP STORY

ARF6 Is an Actionable Node that Orchestrates Oncogenic GNAQ Signaling in Uveal Melanoma

The authors showed that the small GTPase ARF6 acts as a proximal node of oncogenic Gαq signaling to induce all of these downstream pathways as well as β-catenin signaling. [Cancer Cell] Abstract | Graphical Abstract

(Ranked by impact factor of the journal)

DERMAL STEM CELLS & TISSUE REGENERATION

Tumor Suppression in Basal Keratinocytes via Dual Non-Cell-Autonomous Functions of a Na,K-ATPase Beta Subunit

Scientists identified cooperative non-cell-autonomous functions of one and the same gene as a novel mechanism of tumor suppression in basal keratinocytes of zebrafish embryos. [eLife] Abstract | Download Full Article

Re-Epithelialization of Pathological Cutaneous Wounds Is Improved by Local Mineralocorticoid Receptor Antagonism

Researchers hypothesized that dermatological use of mineralocorticoid receptor antagonists may be beneficial by overcoming the negative impact of glucocorticoids treatment on pathological wounds. [J Invest Dermatol] Abstract

Bilayer Cryogel Wound Dressing and Skin Regeneration Grafts for the Treatment of Acute Skin Wounds

The potential of cryogel bilayer wound dressings and skin regenerating grafts for the treatment of surgically created full thickness wounds were evaluated. [ACS Appl Mater Interfaces] Abstract

Deletion of the Epidermis Derived Laminin γ1 Chain Leads to Defects in the Regulation of Late Hair Morphogenesis

To study the function of laminin γ1 containing isoforms in skin development and maturation after birth, researchers generated mice lacking LAMC1 expression in basal keratinocytes using the keratin Cre/loxP system. [Matrix Biol] Abstract

miR-1908 Promotes Scar Formation Post-Burn Wound Healing by Suppressing Ski-Mediated Inflammation and Fibroblast Proliferation

Investigators found that miR-1908 expression was inversely associated with the scar suppressor Ski in normal, burn-wounded, healing and scar dermal tissues in humans. [Cell Tissue Res] Abstract

Heat-Mediated Reduction of Apoptosis in UVB-Damaged Keratinocytes In Vitro and in Human Skin Ex Vivo

Using ex vivo skin models and primary keratinocytes in vitro, researchers showed that UVB plus heat treated keratinocytes exhibit persistent DNA damage, as observed with UVB alone. [BMC Dermatol] Full Article

SKIN CANCERS & DISORDERS

Extracellular Matrix-Specific Caveolin-1 Phosphorylation on Tyrosine 14 Is Linked to Augmented Melanoma Metastasis but Not Tumorigenesis

Investigators recently implicated Caveolin-1 (CAV1) phosphorylation on tyrosine 14 in CAV1-enhanced cell migration. The contribution of this modification to the dual role of CAV1 in cancer remained unexplored. They used in vitro (2D and transendothelial cell migration, invasion) and in vivo (metastasis) assays, as well as genetic and biochemical approaches to address this question in B16F10 murine melanoma cells. [Oncotarget] Full Article

miR-211 Is Epigenetically Regulated by DNMT1 Mediated Methylation and Inhibits EMT of Melanoma Cells by Targeting RAB22A

Researchers verified the expression of miR-211 in melanoma cell lines and observed that its downregulation is associated with increased DNMT1 expression. [Biochem Biophys Res Commun] Abstract

Pigment Production Analysis in Human Melanoma Cells

The authors describe methods to detect changes in melanogenesis in a human melanoma cell line, MNT-1, by analyzing pigment production by measuring the absorbance of melanin present by spectrophotometry, analyzing transcript expression of potent regulators of melanogenesis by quantitative reverse-transcription (RT)PCR, and analyzing protein expression of potent regulators of melanogenesis by Western blot. [Methods Mol Biol] Abstract

Scarless Wound Healing: Finding the Right Cells and Signals

The authors discuss several recent studies that identify exciting approaches for diminishing scar formation. Particular attention will also be paid to the canonical Wnt/β-catenin signaling pathway, which plays an important role in both embryogenesis and tissue repair. [Cell Tissue Res] Abstract | Graphical Abstract

Visit our reviews page to see a complete list of reviews in the dermal cell research field.

WPI Team Awarded Patent for Reprogramming Skin Cells

Cell therapies for a range of serious conditions, including heart attacks, diabetes, and traumatic injuries, will be accelerated by research at Worcester Polytechnic Institute (WPI) that yielded a newly patented method of converting human skin cells into engines of wound healing and tissue regeneration. [Worcester Polytechnic Institute] Press Release

Regeneron and Sanofi Announce That Dupilumab Used with Topical Corticosteroids (TCS) Was Superior to Treatment with TCS Alone in Long-Term Phase III Trial in Inadequately Controlled Moderate-To-Severe Atopic Dermatitis Patients

Regeneron Pharmaceuticals, Inc. and Sanofi announced that a one-year Phase III study, known as LIBERTY AD CHRONOS, evaluating investigational dupilumab met its primary and key secondary endpoints. [Regeneron Pharmaceuticals, Inc.] Press Release

NEW Gordon Research Conference – Notch Signaling in Development, Regeneration & Disease
July 31-August 5, 2016
Lewiston, United States

Visit our events page to see a complete list of events in the dermal cell community.

NEW Research Scientist – Hair Biophysics (L’Oreal)

Scientific Communications and Publishing Coordinator (STEMCELL Technologies Inc.)

Postdoctoral Scientist – Skin Cancer and Aging Group (Cancer Research UK Manchester Institute)

Associate Professor/Professor – Dermatology (The University of Texas MD Anderson Cancer Center)

Scientist – Target Validation (Innate Pharma)

Postdoctoral Positions – Stem Cell Biology and Regenerative Medicine (University of Southern California)

Medical Science Liaison Associate – Skin Diseases (Biofrontera Inc.)

Postdoctoral Fellow – Biology (California Institute for Biomedical Research)

Postdoctoral Positions – Immunology, Cancer, and Stem Cells (University of Connecticut)

Postdoctoral Position – Cancer Biology/Immunology (The University of Texas MD Anderson Cancer Center)

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