Dermal Cell News 2.29 August 15, 2016 | |
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TOP STORYFast Diagnostics of BRAF Mutations in Biopsies from Malignant Melanoma Researchers completed a preliminary clinical trial applying cantilever array sensors to demonstrate identification of a BRAFV600E single-point mutation using total RNA obtained from biopsies of metastatic melanoma of diverse sources. [Nano Lett] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)DERMAL STEM CELLS & TISSUE REGENERATIONNovel H2S Releasing Nano-Fibrous Coating for In Vivo Dermal Wound Regeneration Researchers investigated polycaprolactone (PCL)-JK1 as a wound dressing toward a cutaneous wound model in vivo and found that PCL-JK1 could significantly enhance the wound regeneration compared with PCL scaffold, likely due to the release of hydrogen sulfide (H2S), which results in a broad range of physiological protective functions toward wound. [ACS Appl Mater Interfaces] Abstract Scientists investigated the potential of Pep19-2.5 and the structurally related compound Pep19-4LF for their therapeutic application in bacterial skin infections. [Sci Rep] Full Article SKIN CANCERS & DISORDERSA cooperative therapy of low concentration curcumin combined with red united blue light irradiation was performed to inspect the synergistic effects on the apoptosis, proliferation and autophagy in human melanoma A375 cell. [Sci Rep] Full Article Cell Autonomous or Systemic EGFR Blockade Alters the Immune-Environment in Squamous Cell Carcinomas Cancers forming from keratinocytes genetically depleted of EGFR were smaller than wildtype cancers and had fewer infiltrating FoxP3 Treg cells, lower Foxp3 RNA and a lower percentage of CD4 PD1 positive cells indicating a tumor cell autonomous regulation of its microenvironment. [Int J Cancer] Abstract Detection of Occult Invasion in Melanoma In Situ Researchers investigated the occurrence of occult invasive disease within in situ melanoma by using methods to circumvent potential limitations in prior study designs. [JAMA Dermatol] Abstract Exercise has been previously reported to lower cancer risk through reducing circulating IGF-1 and IGF-1-dependent signaling in a mouse skin cancer model. Researchers investigated the underlying mechanisms by which exercise may down-regulate the IGF-1 pathway via p53 and p53-related regulators in the skin epidermis. [PLoS One] Full Article Scientists found normal and malignant keratinocytes were found to produce different CD44 transcripts upon serum stimulation and subsequent starvation, suggesting that specific CD44 isoforms are involved in tumorigenesis via different CD44-mediated biological pathways. [PLoS One] Full Article Scientists found psoriatic substitutes supplemented with a cocktail of TNF-α, IL-1α, IL-6 and IL-17A showed similar transcriptome alterations to those found in psoriasis. [Regen Med] Abstract | |
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REVIEWSEpidermolysis bullosa serves as a paradigm of heritable skin diseases in which significant progress has been made in identifying the underlying genetic bases and associated aberrant pathways leading from mutations to the phenotype, thus allowing application of precision medicine for this, currently intractable group of diseases. [Matrix Biol] Abstract Visit our reviews page to see a complete list of reviews in the dermal cell research field. | |
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SCIENCE NEWSProvectus Biopharmaceuticals, Inc. announced that a poster presentation titled “Intralesional rose bengal for stage III and IV melanoma” is to be presented. [Press release from Provectus Biopharmaceuticals discussing research presented at European Society for Medical Oncology 2016 Congress, Copenhagen] Press Release | |
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INDUSTRY NEWSUniversity of Pittsburgh Licenses Novel Microneedle Patch to Pittsburgh Company SkinJect Inc. announced its completion of a license with the University of Pittsburgh to its novel, minimally invasive treatment for common forms of non-melanoma skin cancer, basal cell and squamous cell carcinoma. [SkinJect Inc.] Press Release Mallinckrodt plc announced that it has entered into a merger agreement with Stratatech Corporation, a privately held regenerative medicine company focused on the development of unique, proprietary skin substitute products. Developmental products include StrataGraft regenerative skin tissue and a technology platform for genetically enhanced skin tissues. [Mallinckrodt plc] Press Release | |
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POLICY NEWSUK Government Gives Brexit Science Funding Guarantee British scientists say they’re relieved by a government promise to guarantee them funding for existing EU research projects, even after the country leaves the European Union. But the reassurance only partly allays concerns about Brexit’s effect on UK science. [Nature News] Editorial Spiking Genomic Databases with Misinformation Could Protect Patient Privacy Large genomic databases are indispensable for scientists looking for genetic variations associated with diseases. But they come with privacy risks for people who contribute their DNA. A 2013 study showed that hackers could use publicly available information on the Internet to identify people from their anonymized genomic data. [Nature News] Editorial
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EVENTSNEW 4th International Oncology Conference Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Assistant/Associate/Full Professor – Cancer Biology (Michigan State University) NEW Postdoctoral Associate – Cell Biology (Stony Brook University) PhD Position – Regulation of Keratinocyte Cell Death (University of Birmingham) PhD Research Project – Human Tissue Interactions (University of Sheffield) Postdoctoral Fellow – Skin Biology (University of Cincinnati) Postdoctoral Fellow – Department of Pathology and Immunology (University of Geneva) Postdoctoral Researcher – Computational Biology (Helmholtz Association) PhD Studentship – Epithelial Stem Cell Biology (Curtin University) Postdoctoral Fellow – Skin Carcinogenesis (Inserm) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Dermal Cell News Volume 2.29 | Aug 15 2016