Dermal Cell News 2.30 August 22, 2016 | |
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TOP STORYMelanoma miRNA Trafficking Controls Tumor Primary Niche Formation Researchers showed that melanoma cells directly affect the formation of the dermal tumor niche by microRNA trafficking before invasion. [Nat Cell Biol] Abstract | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)DERMAL STEM CELLS & TISSUE REGENERATIONResearchers describe the establishment of a spontaneous immortalized skin keratinocyte cell line derived from the skin of the multimammate rodent Mastomys coucha. [PLoS One] Full Article Scientists showed that in human skin matriptase and prostasin are expressed with an inverse pattern over the course of differentiation. [Biol Open] Full Article SKIN CANCERS & DISORDERSTumor Immune Profiling Predicts Response to Anti–PD-1 Therapy in Human Melanoma Investigators performed multiparameter flow cytometry on freshly isolated metastatic melanoma samples from two cohorts of 20 patients each prior to treatment and correlated the subsequent clinical response with the tumor immune phenotype. [J Clin Invest] Full Article | Press Release Synergistic Effects of Ion Transporter and MAP Kinase Pathway Inhibitors in Melanoma Investigators report that multiple cardiac glycosides, including digitoxin and digoxin, are significantly more toxic to human melanoma cells than normal human cells. [Nat Commun] Full Article 5-Aminolevulinic Acid Coated Microneedles for Photodynamic Therapy of Skin Tumors Investigators evaluated the potential of coated microneedles for improved dermal delivery of 5-aminolevulinic acid, which naturally gets converted by cells of the tissue into a photosensitizer called protoporphyrin IX. [J Control Release] Abstract Scientists investigated the potential of the flavone luteolin-7-glucoside (LUT-7G) as a treatment for psoriasis. They showed that LUT-7G leads to a modification of the cell cycle and the induction of keratinocyte differentiation, with modification of energy, fatty acid, and redox metabolism. [Cell Death Dis] Full Article Researchers identified ATP2C1 as a crucial regulator of epidermal homeostasis through the regulation of oxidative stress. [Sci Rep] Full Article c-Myc is a well-characterized proto-oncogene that induces cellular transformation and modulates programmed cell death. Researchers investigated the effect of c-Myc overexpression in melanoma tumorigenesis. [J Mol Med] Abstract Glucose-Independent Acetate Metabolism Promotes Melanoma Cell Survival and Tumor Growth Scientists showed that glutamine supplementation is not sufficient to prevent loss of cell viability in a subset of glucose-deprived melanoma cells, but synergizes with acetate to support cell survival. [J Biol Chem] Full Article | |
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REVIEWSThe Senescence-Associated Secretory Phenotype: Critical Effector in Skin Cancer and Aging The authors consider the evidence for the senescence-associated secretory phenotype (SASP) and “SASP-like” inflammation in driving skin carcinogenesis, emphasizing how further understanding of both the roles and mechanisms of SASP expression may offer new targets for skin cancer prevention and therapy. [J Invest Dermatol] Abstract Visit our reviews page to see a complete list of reviews in the dermal cell research field. | |
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SCIENCE NEWSStopping Scars before They Form Scientists have developed new compounds that could stop scars from forming in the first place. [Press release from The American Chemical Society discussing research presented at 252nd National Meeting & Exposition of the American Chemical Society, Philadelphia] Press Release | |
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INDUSTRY NEWSPfizer Inc. and Medivation, Inc. announced that they have entered into a definitive merger agreement under which Pfizer will acquire Medivation, a biopharmaceutical company focused on developing and commercializing small molecules for oncology. [Pfizer Inc.] Press Release ScarX Announces Approval for Trial of First Clinically-Promising Scar Reduction Cream ScarX Therapeutics has received approval from Health Canada to begin a Phase I clinical trial of its SCX-001 nefopam cream, a first-of-its-kind topical treatment developed to significantly reduce surgical scarring. [ScarX Therapeutics] Press Release | |
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POLICY NEWSPutin Appoints Church Historian as Science Minister Russian President Vladimir Putin has appointed a church historian as the country’s new science and education minister. The president announced that Olga Vasilyeva would succeed the current science minister, Dmitry Livanov, who will become presidential envoy on trade and economic relations with Ukraine, according to the Russian news agency Interfax. [Nature News] Editorial Obama’s Science Legacy: Betting Big on Biomedical Science Ambitious bids to map the brain and cure cancer have not boosted overall research funding. [Nature News] Editorial Mouse Microbes May Make Scientific Studies Harder to Replicate Experimenters are questioning the potential research impact of the microbiome—a term often used to refer to commensal gut bacteria, but which also includes resident viruses, fungi, protozoa, and single-celled archaea species. [Science] Editorial US Personalized-Medicine Industry Takes Hit from Supreme Court Rejections for US patents related to personalized medicine have spiked after recent Supreme Court decisions tightened the rules for such claims, an analysis of more than 39,000 patent applications reveals. [Nature News] Editorial
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EVENTSNEW European Society for Medical Oncology (ESMO) 2016 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Researcher – Cutaneous Biology (University of Wisconsin in Madison) Assistant/Associate/Full Professor – Cancer Biology (Michigan State University) Research Associate/Senior Research Associate – Applied Genetic Epidemiology (University of Bristol) Postdoctoral Associate – Cell Biology (Stony Brook University) PhD Position – Regulation of Keratinocyte Cell Death (University of Birmingham) PhD Research Project – Human Tissue Interactions (University of Sheffield) Postdoctoral Fellow – Skin Biology (University of Cincinnati) Postdoctoral Fellow – Department of Pathology and Immunology (University of Geneva) Postdoctoral Researcher – Computational Biology (Helmholtz Association) PhD Studentship – Epithelial Stem Cell Biology (Curtin University) Postdoctoral Fellow – Skin Carcinogenesis (Inserm) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Dermal Cell News Volume 2.30 | Aug 22 2016