Dermal Cell News Volume 2.35 | Oct 03 2016

TOP STORY

Keratinocytes Contribute Intrinsically to Psoriasis upon Loss of Tnip1 Function

The authors describe a mouse model based on the human psoriasis susceptibility locus TNIP1, also referred to as ABIN1, whose gene product is a negative regulator of various inflammatory signaling pathways, including the Toll-like receptor pathway in innate immune cells. [Proc Natl Acad Sci USA] Abstract

(Ranked by impact factor of the journal)

DERMAL STEM CELLS & TISSUE REGENERATION

Single-Cell Analysis Reveals IGF-1 Potentiation of Inhibition of the TGF-β/Smad Pathway of Fibrosis in Human Keratocytes In Vitro

Primary human corneal keratocytes under serum-free conditions were used as a model of corneal stromal wounding, with markers of corneal fibrosis and opacity studied under TGF-β2 stimulation. [Sci Rep] Full Article

3D Bioprinting Matrices with Controlled Pore Structure and Release Function Guide In Vitro Self-Organization of Sweat Gland

Scientists bioprinted a 3D matrix as the restrictive niche for direct sweat gland differentiation of epidermal progenitors by different pore structure and reported a long-term gradual transition of differentiated cells into glandular morphogenesis occurs within the 3D construct in vitro. [Sci Rep] Full Article

Ocular Albinism Type 1 Regulates Melanogenesis in Mouse Melanocytes

The authors investigated whether ocular albinism type 1 (OA1) is differentially expressed in the skin of mice with different coat colors and to determine its correlation with coat color establishment in mouse, the expression patterns and tissue distribution characterization of OA1 in the skin of mice with different coat colors were qualitatively and quantitatively analyzed by real-time quantitative PCR, immunofluorescence staining and Western blot [Int J Mol Sci] Full Article

Oral Administration of Antioxidants Improves Skin Wound Healing in Diabetic Mice

Investigators evaluated the effectiveness of the oral administration of antioxidants on skin wound healing acceleration in alloxan-induced diabetic mice. [Wound Repair Regen] Abstract

SKIN CANCERS & DISORDERS

Hepatocyte Growth Factor Renders BRAF Mutant Human Melanoma Cell Lines Resistant to PLX4032 by Downregulating the Pro-Apoptotic BH3-Only Proteins PUMA and BIM

The authors found that hepatocyte growth factor mediates resistance of cMET-expressing BRAF mutant melanoma cells to PLX4032-induced apoptosis through downregulation of PUMA and BIM rather than by increasing the expression of pro-survival BCL-2-like proteins. [Cell Death Differ] Abstract

RAB22A Overexpression Promotes the Tumor Growth of Melanoma

Researchers found that RAB22A mRNA expression was significantly upregulated in melanoma tissues compared to benign nevi, which were significantly higher in metastatic melanoma tissues than primary tissues. [Oncotarget] Full Article

Vemurafenib-Resistant BRAF-V600E-Mutated Melanoma Is Regressed by MEK-Targeting Drug Trametinib, but Not Cobimetinib in a Patient-Derived Orthotopic Xenograft (PDOX) Mouse Model

Scientists used a patient-derived orthotopic xenograft model of melanoma to test sensitivity to three molecularly-targeted drugs and one standard chemotherapeutic. [Oncotarget] Full Article

The Thiirane-Based Selective MT1-MMP/MMP2 Inhibitor ND-322 Reduces Melanoma Tumor Growth and Delays Metastatic Dissemination

Scientists showed that the novel small-molecule inhibitor ND-322 with high selectivity for MT1-MMP and MMP2, effectively inhibits MT1-MMP and MMP2 activity resulting in reduced in vitro melanoma cell growth, migration and invasion. [Pharmacol Res] Abstract

Altered Metabolite Levels in Cancer: Implications for Tumor Biology and Cancer Therapy

The authors discuss the mechanisms that lead to changes in metabolite concentrations in cancer cells, the consequences of these changes for the cells and how they might be exploited to improve cancer therapy. [Nat Rev Cancer] Abstract

Primary and Secondary Chemoprevention of Malignant Melanoma

In this focused review, the authors discuss current findings and analyze the risks and benefits of various agents investigated for the primary and secondary chemoprevention of malignant melanoma. [Am J Clin Dermatol] Abstract

Visit our reviews page to see a complete list of reviews in the dermal cell research field.

Skin Cancer: Drug Combination Could Improve Immunotherapy

The results of studies involving researchers from the MedUni Vienna and Vienna General Hospital Comprehensive Cancer Center showed that the effect of immunotherapy on malignant melanoma can be improved by combining it with other cancer treatments. However, they also showed that this combination can lead to an increase in side-effects. [Press release from Medical University Vienna discussing research presented at the European Dermatology and Venerology Congress, Vienna] Press Release

New Phase III Data Show Significant Efficacy versus Placebo and Superiority of Guselkumab Versus Humira^® In Treatment of Moderate to Severe Plaque Psoriasis

Janssen Research & Development, LLC announced findings from the first of three pivotal Phase III studies evaluating guselkumab, a subcutaneously administered anti-interleukin (IL)-23 monoclonal antibody in late-stage development for the treatment of adults with moderate to severe plaque psoriasis. [Press release from Janssen Research & Development, LLC (PR Newswire Association LLC.) discussing research presented at the 25th European Academy of Dermatology and Venereology (EADV) Congress, Vienna] Press Release

Regeneron and Sanofi Announce Dupilumab Biologics License Application Accepted for Priority Review by U.S. FDA

Regeneron Pharmaceuticals, Inc. and Sanofi announced that the U.S. Food and Drug Administration (FDA) has accepted for priority review the Biologics License Application for dupilumab for the treatment of adult patients with inadequately controlled moderate-to-severe atopic dermatitis, a serious, chronic inflammatory skin disease. [Regeneron Pharmaceuticals, Inc] Press Release

Medicine Nobel for Research on How Cells ‘Eat Themselves’

Molecular biologist Yoshinori Ohsumi has won the 2016 Nobel Prize in Physiology or Medicine for his work in the field of autophagy: the processes by which the cell digests and recycles its own components. [Nature News] Editorial | Press Release

Democratic Databases: Science on GitHub

Scientists are turning to a software–development site to share data and code. [Nature Toolbox] Editorial

Biologists Plan Scoring System for Antibodies

Biomedical experts plan to create a scoring system that will help researchers choose reliable antibodies for their experiments. The only problems: figuring out how such a ranking would work — and getting manufacturers to adopt the standard. [Nature News] Editorial

UK Bioethicists Eye Designer Babies and CRISPR Cows

From designer babies to engineered mosquitoes, advances in genome-editing technologies such as CRISPR–Cas9 have raised the possibility of tremendous scientific advances — and serious ethical concerns. [Nature News] Editorial

NEW Advances in Cell Engineering, Imaging and Screening
November 17-18, 2016
Leuven, Belgium

NEW 2016 World Cancer Congress
October 31-November 3, 2016
Paris, France

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral position – Skin 3D Bioprinting (Inserm)

Pluripotent Stem Cell Faculty (Stanford University)

Postdoctoral Fellowship – Non-Melanoma Skin Cancer (Brigham and Women’s Hospital)

Postdoctoral Researcher – Skin Immunology (University Hospital Lausanne)

Postdoctoral Fellow – Inflammatory Signaling in Psoriasis (The Francis Crick Institute)

Postdoctoral Fellow – Melanoma Biology (Icahn School of Medicine)

Associate Professor/Full Professor – Skin Engineering (Nanyang Technological University)

Postdoctoral Scholar – Cancer Biology (The Pennsylvania State University College of Medicine)

Postdoctoral Researcher – Cutaneous Biology (University of Wisconsin in Madison)

Postdoctoral Associate – Cell Biology (Stony Brook University)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

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